PMID: 8943044Nov 26, 1996Paper

Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection

Proceedings of the National Academy of Sciences of the United States of America
W W HancockL A Turka

Abstract

Recent data implicates a role for the CD40-CD40 ligand (CD40L) pathway in graft rejection. One potential mechanism is direct costimulation of T cells through CD40L. Alternatively, the ability of CD40 stimulation to induce CD80 (B7-1) and CD86 (B7-2) expression on antigen-presenting cells (APCs) has led to the hypothesis that the role of CD40-CD40L interactions in transplant rejection might be indirect, i.e., to promote the costimulatory capacity of APCs. Here, we have used a murine vascularized cardiac allograft model to test this hypothesis. Treatment of the recipients with donor splenocytes and a single dose of anti-CD40L mAb induces long-term graft survival (> 100 days) in all animals. This is associated with marked inhibition of intragraft Th1 cytokine [interferon gamma and interleukin (IL) 2] and IL-12 expression with reciprocal up-regulation of Th2 cytokines (IL-4 and IL-10). In untreated allograft recipients, CD86 is strongly expressed on endothelial cells and infiltrating mononuclear cells of the graft within 24 hr. In contrast, CD80 expression is not seen until 72 hr after engraftment. Anti-CD40L mAb has no detectable effect on CD86 up-regulation, but almost completely abolishes induction of CD80. However, animals trea...Continue Reading

References

May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·Z Razi-WolfH Reiser
Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R J NoelleA Aruffo
Sep 1, 1991·The Journal of Experimental Medicine·P S LinsleyJ A Ledbetter
Jun 30, 1989·Cell·R H Schwartz
Dec 1, 1995·The Journal of Experimental Medicine·M J YellinL Chess
Jul 1, 1994·Immunology Today·C H JuneC B Thompson
Sep 1, 1994·Immunology Today·F H DurieR J Noelle
May 1, 1995·The Journal of Experimental Medicine·M H SayeghL A Turka
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·K KarmannJ S Pober
Jul 1, 1995·The Journal of Experimental Medicine·D HollenbaughA Aruffo
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·D C ParkerA A Rossini
Apr 1, 1993·The Journal of Experimental Medicine·E A Ranheim, T J Kipps
Aug 1, 1993·The Journal of Experimental Medicine·M R AldersonM K Spriggs
Jan 28, 1994·Cell·C A Janeway, K Bottomly
Jun 27, 1994·Transplantation·T C PearsonC P Larsen
Oct 1, 1995·Journal of the American Society of Nephrology : JASN·M H Sayegh, L A Turka

❮ Previous
Next ❯

Citations

Feb 10, 2000·Springer Seminars in Immunopathology·N A MitchisonB Müller
Sep 1, 2005·Cancer Immunology, Immunotherapy : CII·Masahiro AsakageHirokazu Nagawa
Jan 1, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Elizabeth Ingulli
Mar 27, 2001·Transplantation Proceedings·B FellströmL Zezina
Mar 27, 2001·Transplantation Proceedings·J S BillingK J Wood
Mar 27, 2001·Transplantation Proceedings·Y OhashiM Yamaguchi
Jan 5, 2000·Transplantation Proceedings·M A MasriG Kamel
Jul 2, 2003·Molecular Immunology·Marwan A Masri
Oct 18, 2001·Clinics in Dermatology·N NajafianM H Sayegh
Sep 28, 2000·Current Opinion in Immunology·A M WaagaN L Tilney
Sep 28, 2000·Current Opinion in Immunology·S J Knechtle
Nov 22, 1997·Current Opinion in Immunology·C P Larsen, T C Pearson
Oct 6, 1999·Current Opinion in Immunology·T KawaiA B Cosimi
Jun 26, 1998·Transplant Immunology·G MengJ M Thomas
Aug 30, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Paloma RiquelmeJames A Hutchinson
Jun 7, 2005·Nature Medicine·Robert I LechlerLaurence A Turka
Dec 3, 2003·Nature Medicine·Zihao WuLaurence A Turka
Nov 7, 2001·Scandinavian Journal of Immunology·I A MacPheeD B Oliveira
May 11, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Adam S BartlettStephen R Munn
Jun 19, 1998·The New England Journal of Medicine·M H Sayegh, L A Turka
Dec 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ivana R FerrerMandy L Ford
Nov 21, 2000·The Journal of Experimental Medicine·W W HancockC Gerard
Apr 17, 2001·The Journal of Experimental Medicine·W W HancockA D Luster
Mar 20, 2002·The Journal of Experimental Medicine·Qunrui YeWayne W Hancock
Apr 6, 2005·The Journal of Experimental Medicine·Iris LeeWayne W Hancock
Feb 13, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ying QianM Reza Dana
Feb 16, 2002·Journal of Hematotherapy & Stem Cell Research·Alexander Schmeisser, Ruth H Strasser
May 27, 1997·Transplantation·T C PearsonC P Larsen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.