Costimulatory molecule OX40/OX40L expression in ductal carcinoma in situ and invasive ductal carcinoma of breast: an immunohistochemistry-based pilot study

Pathology, Research and Practice
Fang XieXueguang Zhang

Abstract

OX40, a membrane-bound member of the tumor-necrosis-factor-receptor (TNFR) superfamily, plays an important role in proliferation, survival and infiltration of activated T cells via binding to OX40L. Recent studies indicate that OX40/OX40L system mediates the adhesion and infiltration of adult T cell leukemia (ATL). Previously, we detected OX40 expression in breast carcinoma cell lines and tissues. The correlation of expression of OX40 and OX40L and clinical features in breast carcinogenesis, however, has not been well characterized. The expression of OX40 and OX40L in 107 invasive ductal carcinomas (IDCa), 9 ductal carcinomas in situ (DCIS), and 31 fibroadenomas from breast tissues and its relationship with the clinical features were determined using immunohistochemistry (peroxidase-conjugated polymer method, ChemMate™ Envision™ Detection kit). The positive immunostaining rates for OX40 in IDCa, DCIS and fibroadenomas from breast tissues were 85.0%, 66.7% and 38.7% respectively, showing a significant difference in OX40 expression among IDCa, DCIS and fibroadenoma of breast (z=5.206, P=0.001). Increased staining intensity of OX40 was associated with TNM stages (z=2.112, P=0.017). Meanwhile, a relation of OX40 expression with lym...Continue Reading

References

Aug 1, 1994·The Journal of Experimental Medicine·W R GodfreyE G Engleman
Nov 25, 1998·Seminars in Immunology·L A Gravestein, J Borst
May 11, 2001·Japanese Journal of Cancer Research : Gann·N TakasawaK Sugamura
Sep 17, 2003·Nature Reviews. Immunology·Michael Croft
Jan 8, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Sigrid E SandnerMohamed H Sayegh
Mar 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Barbara TringlerKenneth R Shroyer
Apr 26, 2006·The British Journal of Dermatology·T YamaguchiM Kikuchi
Oct 18, 2006·The Journal of Experimental Medicine·Claudia ChiodoniMario P Colombo
Dec 22, 2006·European Journal of Immunology·Carl E RubyAndrew D Weinberg
Jun 20, 2008·Journal of Leukocyte Biology·Antonella D'AmbrosioMonica Boirivant
Nov 26, 2008·Circulation Research·Israel GotsmanAndrew H Lichtman

❮ Previous
Next ❯

Citations

Feb 23, 2011·The Journal of Experimental Medicine·Alexander Pedroza-GonzalezA Karolina Palucka
Dec 10, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sandrine AspeslaghAurélien Marabelle
Feb 14, 2015·Current Oncology Reports·Brenda Ernst, Karen S Anderson
May 8, 2019·Cancers·Sebastian ChrétienTheodoros Foukakis
Oct 27, 2017·Oncotarget·Yecheng LiChungen Xing
Sep 10, 2020·Cancer Immunology, Immunotherapy : CII·Ali SafarzadehNicola Silvestris
Jan 14, 2017·International Journal of Environmental Research and Public Health·Lin-Yu YuXiao-Ping Chen
Sep 10, 2020·Journal for Immunotherapy of Cancer·Lucia Campos CarrascosaJaap Kwekkeboom
Oct 7, 2020·Journal for Immunotherapy of Cancer·Yeonjoo ChoiJoud Hajjar
Jan 1, 2021·Luminescence : the Journal of Biological and Chemical Luminescence·Meng LiJunzhi Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.