Abstract
OX40, a membrane-bound member of the tumor-necrosis-factor-receptor (TNFR) superfamily, plays an important role in proliferation, survival and infiltration of activated T cells via binding to OX40L. Recent studies indicate that OX40/OX40L system mediates the adhesion and infiltration of adult T cell leukemia (ATL). Previously, we detected OX40 expression in breast carcinoma cell lines and tissues. The correlation of expression of OX40 and OX40L and clinical features in breast carcinogenesis, however, has not been well characterized. The expression of OX40 and OX40L in 107 invasive ductal carcinomas (IDCa), 9 ductal carcinomas in situ (DCIS), and 31 fibroadenomas from breast tissues and its relationship with the clinical features were determined using immunohistochemistry (peroxidase-conjugated polymer method, ChemMate™ Envision™ Detection kit). The positive immunostaining rates for OX40 in IDCa, DCIS and fibroadenomas from breast tissues were 85.0%, 66.7% and 38.7% respectively, showing a significant difference in OX40 expression among IDCa, DCIS and fibroadenoma of breast (z=5.206, P=0.001). Increased staining intensity of OX40 was associated with TNM stages (z=2.112, P=0.017). Meanwhile, a relation of OX40 expression with lym...Continue Reading
References
Nov 1, 1991·British Journal of Haematology·M Shimoyama
Aug 1, 1994·The Journal of Experimental Medicine·W R GodfreyE G Engleman
Dec 1, 1993·Chest·I HaraS Yokoo
May 1, 1996·The Journal of Experimental Medicine·A ImuraT Uchiyama
Jan 28, 1998·Archives of Dermatological Research·Y MatsumuraS Imamura
Nov 25, 1998·Seminars in Immunology·L A Gravestein, J Borst
Aug 28, 1999·International Immunology·C AbbalJ Pène
Jan 19, 2000·The Journal of Experimental Medicine·P Lane
Jan 19, 2000·The Journal of Experimental Medicine·H AkibaK Okumura
Feb 9, 2000·American Journal of Clinical Pathology·T W JacobsS J Schnitt
May 11, 2001·Japanese Journal of Cancer Research : Gann·N TakasawaK Sugamura
Jul 4, 2001·Journal of Virology·Y TakahashiN Yamamoto
Feb 13, 2002·Internal Medicine·Teruto HashiguchiIkuro Maruyama
Mar 16, 2002·Cytokine·Elizabeth DaroHilary J McKenna
Sep 6, 2003·Blood·Takeshi TsuchiyaMasahiro Kikuchi
Sep 17, 2003·Nature Reviews. Immunology·Michael Croft
Mar 6, 2004·Cell Death and Differentiation·S HongK Liao
Oct 22, 2004·Tissue Antigens·Q WangX Zhang
Jan 8, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Sigrid E SandnerMohamed H Sayegh
Mar 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Barbara TringlerKenneth R Shroyer
Jan 21, 2006·Immunology·Itzhak Mendel, Ethan M Shevach
Feb 28, 2006·Journal of Virology·Aymeric de ParsevalJohn H Elder
Apr 26, 2006·Tissue Antigens·F XieX Zhang
Apr 26, 2006·The British Journal of Dermatology·T YamaguchiM Kikuchi
Oct 18, 2006·The Journal of Experimental Medicine·Claudia ChiodoniMario P Colombo
Dec 22, 2006·European Journal of Immunology·Carl E RubyAndrew D Weinberg
Jun 20, 2008·Journal of Leukocyte Biology·Antonella D'AmbrosioMonica Boirivant
Nov 26, 2008·Circulation Research·Israel GotsmanAndrew H Lichtman
Oct 25, 2011·Immunological Reviews·David R WithersPeter J L Lane
Citations
Feb 23, 2011·The Journal of Experimental Medicine·Alexander Pedroza-GonzalezA Karolina Palucka
Jul 8, 2011·Molecular Pharmaceutics·Srikanth YellayiJames G Hecker
Aug 2, 2011·Pathology, Research and Practice·Zhen WangFang Xie
Dec 10, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sandrine AspeslaghAurélien Marabelle
Nov 2, 2012·Nucleic Acid Therapeutics·Elizabeth D PraticoSmita K Nair
Apr 9, 2016·Oncoimmunology·Honggeng GuanFang Xie
Feb 14, 2015·Current Oncology Reports·Brenda Ernst, Karen S Anderson
Aug 8, 2018·Anti-cancer Drugs·Tingting ZhouLing Wang
May 8, 2019·Cancers·Sebastian ChrétienTheodoros Foukakis
Oct 27, 2017·Oncotarget·Yecheng LiChungen Xing
Feb 1, 2018·Oncotarget·Ha ZhuQiuyan Liu
Sep 10, 2020·Cancer Immunology, Immunotherapy : CII·Ali SafarzadehNicola Silvestris
Jan 14, 2017·International Journal of Environmental Research and Public Health·Lin-Yu YuXiao-Ping Chen
Sep 10, 2020·Journal for Immunotherapy of Cancer·Lucia Campos CarrascosaJaap Kwekkeboom
Oct 7, 2020·Journal for Immunotherapy of Cancer·Yeonjoo ChoiJoud Hajjar
Jan 1, 2021·Luminescence : the Journal of Biological and Chemical Luminescence·Meng LiJunzhi Wang
Jun 17, 2021·Aging·Xiaoru SunFuzhong Xue