Costimulatory molecules and cytokine production by T lymphocytes in common variable immunodeficiency disease

Scandinavian Journal of Immunology
J PonsN Matamoros

Abstract

Common variable immunodeficiency (CVID) is a heterogeneous syndrome characterized by hypogammaglobulinaemia and recurrent infections. Although early works pointed to a primary B-lymphocyte defect as a cause of the disease, a failure in T-lymphocyte cooperation has also been suggested. T cells exert their costimulatory function through either membrane costimulatory molecules or secreted cytokines, both having an influence in the development of the humoral response. The aim of our study was to evaluate whether an abnormal expression and induction of costimulatory molecules or alterations in the production of cytokines by T cells cause deficient T/B cooperation in CVID patients. We studied the expression and upregulation of costimulatory molecules (CD28, CD40L/CD154 and CTLA-4/CD152) and production of cytokines (IL-2, IL-4, IL-6, IL-10, IFN-gamma and TNF-alpha) in purified T lymphocytes from CVID patients stimulated with optimal doses of anti-CD3 or suboptimal doses of anti-CD3 and anti-CD28. Stimulated T cells from CVID patients expressed normal levels of CD28, CD40L/CD154 and CTLA-4/CD152 when compared with controls. Except for higher production of IL-4 after stimulation with anti-CD3, T cells of CVID patients produced similar a...Continue Reading

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Citations

Jan 23, 2016·Molecular Immunology·Reza YazdaniAsghar Aghamohammadi
Aug 2, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Marcela VlkovaPaul A Blair
Jan 26, 2010·Human Immunology·Nima RezaeiRobert C Read
Dec 17, 2008·Clinical and Experimental Immunology·N RezaeiA Aghamohammadi
Apr 9, 2016·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Laura Berrón-RuizLaura Bonifaz
Jul 10, 2016·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Camila de LolloMaria Notomi Sato
Sep 17, 2014·Expert Review of Clinical Immunology·Asghar AghamohammadiNima Rezaei

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