PMID: 11327084May 1, 2001Paper

Costimulatory molecules in human periodontal disease tissues

Journal of Periodontal Research
E GemmellG J Seymour

Abstract

An immunoperoxidase technique was used to examine CD28, CD152, CD80 and CD86 positive cells in gingival biopsies from 21 healthy/gingivitis and 26 periodontitis subjects. The samples were placed into 3 groups (small, intermediate, large) according to the size of the infiltrate. The percent CD28+ T cells in the connective tissue infiltrates was highly variable with no differences between the healthy/gingivitis and periodontitis groups. While there was an increase in positive cells in intermediate infiltrates from both healthy/gingivitis (28.5%) and periodontitis (21.4%) patients compared with small infiltrates (8.6% and 11.8%, respectively), this was not significant, although the percent CD28+ T cells did increase significantly in tissues with increased proportions of B cells relative to T cells (p=0.047). A mean of less than 5% infiltrating T cells were CD152+ which was significantly lower than the mean percent CD28+ T cells in intermediate healthy/gingivitis lesions (p = 0.021). The mean percent CD80+ and CD86+ B cells and macrophages was 1-7% and 8-16%, respectively, the difference being significant in intermediate healthy/gingivitis tissues (p = 0.012). Analysis of these cells in relation to increasing numbers of B cells in ...Continue Reading

Citations

May 11, 2012·Joint, Bone, Spine : Revue Du Rhumatisme·Thao PhamJean Sibilia
Dec 27, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hisanori DomonKazuhisa Yamazaki
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Sep 1, 2005·Journal of Clinical Periodontology·Tord Berglundh, Mauro Donati
Apr 27, 2004·Periodontology 2000·Kazuhisa Yamazaki, Takako Nakajima
Apr 27, 2004·Periodontology 2000·Erica Gemmell, Gregory J Seymour
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