Costs and clinical outcomes of patients with diffuse large B-cell lymphoma in first remission: role of PET/CT surveillance

The Korean Journal of Internal Medicine
Koung Jin SuhDae Seog Heo

Abstract

The role of [18F]-f luorodeoxyglucose positron emission tomography-computed tomography (PET/CT) in patients with diffuse large B-cell lymphoma (DLBCL) in first remission is unclear. Medical costs within the first 3 years of treatment completion and clinical outcomes of 118 patients with DLBCL in first remission with and without surveillance PET/CT (PET/CT [+] group [n = 76] and PET/CT [-] group [n = 42], respectively) were retrospectively analyzed. In a propensity matched cohort with adjustment for International Prognostic Index risk and relapse, the PET/CT (+) group was shown to have similar medical costs as the PET/CT (-) group. Relapse-free survival (RFS) and overall survival (OS) were comparable between the two groups (median RFS not reached [NR] for both groups, p = 0.133; median OS NR, p = 0.542). Among 76 patients with surveillance PET/CT, 31 (40.8%) had findings suggestive of recurrence and 16 of these (51.6%) were later confirmed to have recurrent disease. Fifteen patients (48.4%) were confirmed to not have recurrence after follow-up CT or PET/CT evaluation (n = 10) and biopsy (n = 4). None of the patients with negative PET/CT findings had disease recurrence. Sensitivity, specificity, positive predictive value, and neg...Continue Reading

References

May 4, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P FeugierB Coiffier
Jun 16, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laurie H SehnJoseph M Connors
Oct 10, 2006·Seminars in Hematology·Gerhard HeldUNKNOWN German High-Grade Non-Hodgkin-Lymphoma Study Group
Mar 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pier Luigi ZinzaniMichele Baccarani
Feb 9, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·U PetrauschN G Schäefer
Jun 14, 2014·Journal of the National Comprehensive Cancer Network : JNCCN·Andrew D ZelenetzHema Sundar
Aug 13, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce D ChesonT Andrew Lister
Oct 1, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carrie A ThompsonBrian K Link
Apr 1, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Scott F HuntingtonJalpa A Doshi
Jul 24, 2015·Radiology·Sarah A JohnsonJürgen Rademaker
Sep 1, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H TillyUNKNOWN ESMO Guidelines Committee

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Methods Mentioned

BETA
biopsy

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SPSS
GraphPad Prism

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