Costs and effects of various analgesic treatments for patients with rheumatoid arthritis and osteoarthritis in the Netherlands

Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Maiwenn J AlMatthijs Janssen

Abstract

To assess the balance between costs and upper gastrointestinal (GI) side effects of treatment with celecoxib, nonsteroidal antiinflammatory drugs (NSAIDs) alone, NSAID plus misoprostol, NSAID plus histamine-2 receptor antagonist (H(2)RA), NSAID plus proton pump inhibitor (PPI), and Arthrotec in The Netherlands. A model was used to convene data from various sources on the probability of GI side effects and resource use. The probabilities of GI side effects for celecoxib and NSAIDs alone were derived from trial data. Calculations were based on 6 months of treatment, and were from a societal perspective. Distinction was made between low-, medium-, and high-risk patients. An extensive probabilistic sensitivity analysis was performed to address uncertainty. Assuming an average patient, the total costs per 6 months of therapy were: celecoxib 255 Euro, NSAIDs alone 166 Euro, NSAID plus misoprostol 285 Euro, NSAID plus H(2)RA 284 Euro, NSAID plus PPI 243 Euro, and Arthrotec 187 Euro. Treatment with celecoxib was associated with the lowest number of GI side effects and related deaths. Incremental costs per life-year saved for Arthrotec compared to NSAIDs alone were 5676 Euro for all patients and 526 Euro for medium-to-high-risk patients...Continue Reading

References

Jan 1, 1992·Scandinavian Journal of Rheumatology. Supplement·J F Fries
Sep 1, 1991·The American Journal of Medicine·J F FriesB A Michel
Jan 1, 1985·Medical Decision Making : an International Journal of the Society for Medical Decision Making·P DoubiletB J McNeil
Sep 1, 1994·Health Economics·B A van HoutF F Rutten
Aug 6, 1998·Alimentary Pharmacology & Therapeutics·D CullenC J Hawkey
Jan 8, 1996·PharmacoEconomics·G Karlsson, M Johannesson
Dec 2, 1999·JAMA : the Journal of the American Medical Association·L S SimonG S Geis
Jun 1, 2002·BMJ : British Medical Journal·Peter JüniPaul A Dieppe
May 21, 2003·Annals of Internal Medicine·Brennan M R SpiegelIan M Gralnek
Oct 31, 2003·Rheumatology·M C J M SturkenboomJ L Goldstein
Dec 5, 2003·Alimentary Pharmacology & Therapeutics·M C J M SturkenboomJ L Goldstein
Apr 14, 2006·Basic & Clinical Pharmacology & Toxicology·Sonia Hernández-DíazLuis A García Rodríguez

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Citations

Apr 26, 2013·Applied Health Economics and Health Policy·Ronald C WielageMichael Happich
Nov 12, 2013·Applied Health Economics and Health Policy·Ronald C WielageMichael Happich
Sep 14, 2012·Expert Review of Pharmacoeconomics & Outcomes Research·Rachel HuelinJoaquin F Mould
Oct 1, 2015·Social Science & Medicine·Marieke Krol, Werner Brouwer
Aug 31, 2012·Pain Practice : the Official Journal of World Institute of Pain·Anwar Z ZeidanStephan A Schug
Aug 21, 2013·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·N L de GrootM G H van Oijen
Oct 30, 2016·Clinical Therapeutics·Deirdre MladsiKenneth Saag
Mar 10, 2017·Postgraduate Medicine·John D Loeser, Michael E Schatman
Aug 18, 2020·Arthritis Care & Research·Ting ZhaoAndrew J Palmer

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