Costs and persistence of carbonic anhydrase inhibitor versus alpha-2 agonists, associated with beta-blockers, in glaucoma and ocular hypertension: an analysis of the UK-GPRD database

Current Medical Research and Opinion
Antoine Lafuma, G Berdeaux

Abstract

To compare the effectiveness and associated costs of carbonic anhydrase inhibitors + beta-blocker versus alpha-2 adrenergic agonists + beta-blocker in glaucoma therapy, as documented by The United Kingdom General Practitioner Research Database (UK-GPRD). Patient chart analysis. Patient records were screened for diagnoses of ocular hypertension or glaucoma, and for surgery, laser therapy or medication specific to glaucoma. Selected patients were those prescribed either carbonic anhydrase inhibitors + beta-blocker or alpha-2 adrenergic agonists + beta-blocker. Treatment failure was defined as a glaucoma prescription change, i.e. addition, cessation or replacement of medication, surgery or laser therapy. Times to treatment failure were compared with an adjusted Cox model. Treatment persistence and cost. Included patients were those treated with either carbonic anhydrase inhibitors + beta-blocker (n = 5581) or alpha-2 adrenergic agonists + beta-blocker (n = 1164). The average age at diagnosis was 68.1 years and 48.2% were male. Treatment failure at one year was significantly (p < 0.001) less frequent after carbonic anhydrase inhibitors + beta-blocker (57% of patients) than after alpha-2 adrenergic agonists + beta-blocker (64.3%). T...Continue Reading

References

Nov 24, 1998·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·G KobeltG K Krieglstein
May 8, 1995·PharmacoEconomics·D Coyle, M Drummond
Nov 30, 1999·American Journal of Ophthalmology·R G FiscellaM Viana
Aug 6, 2000·American Journal of Ophthalmology·W C StewartJ A Stewart
Nov 14, 2001·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·J HjelmgrenF Andersson
Aug 10, 2002·Journal of Glaucoma·Steven D VoldJohn Jackimiec
Oct 9, 2002·Archives of Ophthalmology·Anders HeijlUNKNOWN Early Manifest Glaucoma Trial Group
Jan 14, 2003·Archives of Ophthalmology·M Cristina LeskeUNKNOWN Early Manifest Glaucoma Trial Group
Apr 17, 2003·Current Opinion in Ophthalmology·Camille Hylton, Alan L Robin
Jun 18, 2003·Clinical Therapeutics·Gregory ReardonEssy Mozaffari
Dec 31, 2003·American Journal of Ophthalmology·Robert PlattEssy Mozaffari
Jul 1, 2004·Journal of Glaucoma·Philippe DenisGilles Berdeaux
Mar 5, 2005·Ophthalmology·Stefano MigliorUNKNOWN European Glaucoma Prevention Study (EGPS) Group
May 10, 2005·Ophthalmology·Alan L Robin, David Covert
Oct 18, 2005·American Journal of Ophthalmology·Beth L NordstromAlexander M Walker
Feb 21, 2006·The British Journal of Ophthalmology·H A Quigley, A T Broman
Sep 27, 2007·Clinical & Experimental Ophthalmology·Julian L Rait, Michael A Adena

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Citations

Apr 29, 2011·Experimental Eye Research·Stella Arthur, Louis B Cantor
Aug 4, 2010·American Journal of Ophthalmology·Vicky H LuChristine Y Lu
Aug 13, 2011·Acta Ophthalmologica·Jens OlsenJesper Skov

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