Costs associated with failure to respond to treatment among patients with rheumatoid arthritis initiating TNFi therapy: a retrospective claims analysis

Arthritis Research & Therapy
Michael GrabnerJeffrey R Curtis

Abstract

Tumor necrosis factor inhibitors (TNFi) are common second-line treatments for rheumatoid arthritis (RA). This study was designed to compare the real-world clinical and economic outcomes between patients with RA who responded to TNFi therapy and those who did not. For this retrospective cohort analysis we used medical and pharmacy claims from members of 14 large U.S. commercial health plans represented in the HealthCore Integrated Research Database. Adult patients (aged ≥18 years) diagnosed with RA and initiating TNFi therapy (index date) between 1 January 2007 and 30 April 2014 were included in the study. Treatment response was assessed using a previously developed and validated claims-based algorithm. Patients classified as treatment responders in the 12 months postindex were matched 1:1 to nonresponders on important baseline characteristics, including sex, age, index TNFi agent, and comorbidities. The matched cohorts were then compared on their all-cause and RA-related healthcare resource use, and costs were assessed from a payer perspective during the first, second, and third years postindex using parametric tests, regressions, and a nonparametric bootstrap. A total of 7797 patients met the study inclusion criteria, among wh...Continue Reading

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Citations

Oct 18, 2018·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Susana SecaHenry J Greten
Jul 28, 2020·Journal of Managed Care & Specialty Pharmacy·Mahdi GharaibehBradley S Stolshek
Apr 29, 2021·Current Rheumatology Reports·David F L LiewPhilip C Robinson

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