Costs associated with non-medical switching from originator to biosimilar etanercept in patients with rheumatoid arthritis in the UK

Journal of Medical Economics
Miriam TaralloStamatia T Alexopoulos

Abstract

Aims: To estimate the cost impact of non-medical switching from originator to biosimilar etanercept in stable patients with rheumatoid arthritis (RA) in the UK. Materials and methods: A cohort-based decision tree model was developed with a 1-year time horizon. The model population included patients with stable RA (patients who responded to originator etanercept treatment with no treatment changes in the previous 6 months). Patients could undergo a non-medical switch to a biosimilar and then switch treatment again, if medically required, after 3-6 months. Data on the proportion of patients switching therapies, baseline healthcare resource use, and impact of switching on resource use were sourced from a survey of 150 rheumatologists from EU5 markets (France, Germany, Italy, Spain, UK). The average impact of switching was evaluated as mean values for change in resource utilization due to switching. Also, low- and high-impact scenarios (lower and upper values of the 95% confidence intervals for change in resource utilization due to switching) were modelled as sensitivity analyses. Cost data came from published UK sources. Results: The model assumed that 5,000 patients were treated with originator etanercept, with 1,259 (25.2%) swit...Continue Reading

References

Jan 10, 2013·Journal of Medical Economics·Sean D SullivanSarah Ringold
May 20, 2015·Clinical and Molecular Allergy : CMA·Carlo AgostiniEnrico Maggi
Nov 5, 2015·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·L RuffJ W Gommers
Nov 5, 2015·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·L RuffJ W Gommers
Nov 5, 2015·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·S W Kay, J F Kay
Nov 1, 2014·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·P ZhangY Qian
Nov 3, 2016·Indian Journal of Palliative Care·S H ChandrashekharaSushma Bhatnagar
Feb 2, 2017·Digestive Diseases·Jørgen Jahnsen, Kristin Kaasen Jørgensen
Sep 6, 2017·Current Medical Research and Opinion·Allan GibofskyDavid T Rubin
Dec 29, 2017·PloS One·Evelien MoorkensSteven Simoens
Mar 2, 2018·Annals of the Rheumatic Diseases·A V Ramanan, Catherine Guly
May 15, 2018·Diabetes, Obesity & Metabolism·Clifford J Bailey
Sep 22, 2018·Reumatologia·Piotr WilandJulia Feldman

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