Costs associated with transfusion therapy in patients with myelodysplastic syndromes in Sweden: a nationwide retrospective cohort study.

Vox Sanguinis
Jingcheng ZhaoGustaf Edgren

Abstract

Blood transfusion is a cornerstone therapy for many patients with myelodysplastic syndromes (MDS), but ranges from few to no transfusions to intensive transfusion therapy. To date, no large studies have described transfusion use or costs for patients with MDS, accounting for the range of disease severity. A nationwide cohort study was conducted with all patients diagnosed with MDS in Sweden between 2008 and 2017, based on the Swedish MDS register and the Swedish part of the Scandinavian Donations and Transfusions Database 3 (SCANDAT3-S). Patients were followed from diagnosis until death, emigration, allogeneic hematopoietic stem cell transplantation or end of follow-up. Average cumulative transfusion count and costs over time were calculated, stratified by the revised international prognostic scoring system (IPSS-R) and age at diagnosis. Costs calculations used data on incident transfusions and laboratory testing and were divided into: direct material costs, direct labour costs and laboratory costs. In total, 2311 patients were included in the cohort. In the first four years after diagnosis, patients in the very low IPSS-R category received on average 25 red cell (95% confidence interval, 20-32) and 4 (3-7) platelet transfusion...Continue Reading

References

Jun 9, 2009·European Journal of Epidemiology·Jonas F LudvigssonAnders Ekbom
Jul 13, 2013·Journal of the National Comprehensive Cancer Network : JNCCN·Peter L GreenbergMaoko Naganuma
Jan 13, 2019·Leukemia·Detlef HaaseUNKNOWN International Working Group for MDS Molecular Prognostic Committee

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Citations

Sep 5, 2021·Transfusion·Johanne RozemaUNKNOWN on behalf of the HemoBase Population Registry Consortium

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Software Mentioned

SAS Statistical Analysis

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