Costs of novel tuberculosis diagnostics--will countries be able to afford it?

The Journal of Infectious Diseases
Andrea PantojaClaudia M Denkinger

Abstract

Four priority target product profiles for the development of diagnostic tests for tuberculosis were identified: 1) Rapid sputum-based (RSP), 2) non-sputum Biomarker-based (BMT), 3) triage test followed by confirmatory test (TT), and 4) drug-susceptibility testing (DST). We assessed the cost of the new tests in suitable strategies and of the conventional diagnosis of tuberculosis as per World Health Organization guidelines, in 36 high tuberculosis and MDR burden countries. Costs were then compared to the available funding for tuberculosis at country level. Costs of diagnosing tuberculosis using RSP ranged US$93-187 million/year; if RSP unit cost is of US$2-4 it would be lower/similar cost than conventional strategy with sputum smear microscopy (US$ 119 million/year). Using BMT (with unit cost of US$2-4) would cost US$70-121 million/year and be lower/comparable cost than conventional diagnostics. Using TT with TPP characteristics (unit cost of US$1-2) followed by Xpert would reduce diagnostic costs up to US$36 million/year. Costs of using different novel DST strategies for the diagnosis of drug resistance would be higher compared with conventional diagnosis. Introducing a TT or a biomarker test with optimal characteristics would ...Continue Reading

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Citations

Mar 25, 2016·Infectious Diseases of Poverty·Rachel M Anderson de CuevasLuis E Cuevas
Mar 15, 2015·The Journal of Infectious Diseases·Madhukar Pai, Marco Schito
Mar 15, 2015·The Journal of Infectious Diseases·Sandra V KikMadhukar Pai
Aug 11, 2017·Journal of Clinical Microbiology·Mary A De GrooteUrs A Ochsner
Feb 6, 2018·Chonnam Medical Journal·Fariz NurwidyaFaisal Yunus
Aug 9, 2017·African Journal of Laboratory Medicine·Ishani PathmanathanHeather Alexander
Jul 19, 2017·The American Journal of Tropical Medicine and Hygiene·Matthew L Robinson, Yukari C Manabe
Sep 29, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Chunyang LyuYongmei Jiang
Aug 28, 2021·Diagnostics·Darius Riziki MartinMervin Meyer

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