Cosupplementation with a synthetic, lipid-soluble polyphenol and vitamin C inhibits oxidative damage and improves vascular function yet does not inhibit acute renal injury in an animal model of rhabdomyolysis

Free Radical Biology & Medicine
Ludwig GroeblerPaul K Witting

Abstract

We investigated whether cosupplementation with synthetic tetra-tert-butyl bisphenol (BP) and vitamin C (Vit C) ameliorated oxidative stress and acute kidney injury (AKI) in an animal model of acute rhabdomyolysis (RM). Rats were divided into groups: Sham and Control (normal chow), and BP (receiving 0.12% w/w BP in the diet; 4 weeks) with or without Vit C (100mg/kg ascorbate in PBS ip at 72, 48, and 24h before RM induction). All animals (except the Sham) were treated with 50% v/v glycerol/PBS (6 mL/kg injected into the hind leg) to induce RM. After 24h, urine, plasma, kidneys, and aortae were harvested. Lipid oxidation (assessed as cholesteryl ester hydroperoxides and hydroxides and F(2)-isoprostanes accumulation) increased in the kidney and plasma and this was coupled with decreased aortic levels of cyclic guanylylmonophosphate (cGMP). In renal tissues, RM stimulated glutathione peroxidase (GPx)-4, superoxide dismutase (SOD)-1/2 and nuclear factor kappa-beta (NFκβ) gene expression and promoted AKI as judged by formation of tubular casts, damaged epithelia, and increased urinary levels of total protein, kidney-injury molecule-1 (KIM-1), and clusterin. Supplementation with BP±Vit C inhibited the two indices of lipid oxidation, do...Continue Reading

References

Oct 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·C SuarnaR Stocker
Jul 1, 1995·The International Journal of Biochemistry & Cell Biology·M E Rosenberg, J Silkensen
Jun 1, 1993·Kidney International·L M ShulmanH E Eliahou
Aug 1, 1997·Burns : Journal of the International Society for Burn Injuries·D Lazarus, D A Hudson
Jan 5, 1999·Nephron·T H Steele
Jan 26, 1999·Archives of Biochemistry and Biophysics·H OstdalM J Davies
Jan 28, 1999·Biochemical and Biophysical Research Communications·S IshizukaS Horikawa
Feb 5, 1999·The Journal of Trauma·M T ChrysopouloD N Herndon
Apr 20, 1999·Burns : Journal of the International Society for Burn Injuries·C HolmW Mühlbauer
Mar 24, 2000·Experimental Nephrology·S Holt, K Moore
Nov 30, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R DonadelliC Zoja
Jun 30, 2001·Intensive Care Medicine·S G Holt, K P Moore
Jun 4, 2002·DNA and Cell Biology·Nathalie Hill-KapturczakAnupam Agarwal
Feb 7, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Pablo A Ortiz, Jeffrey L Garvin
Sep 12, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Vikas ChanderKanwaljit Chopra
Jul 9, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ramón RodrigoGonzalo Rivera
Aug 21, 2004·Biological Chemistry·Angelo AzziJean-Marc Zingg
Sep 4, 2004·Antioxidants & Redox Signaling·Roland Stocker
Oct 14, 2004·Clinical and Experimental Pharmacology & Physiology·Nurettin AydogduKadir Kaymak
Nov 19, 2004·Antioxidants & Redox Signaling·Brandon J ReederMichael T Wilson
Jan 15, 2005·Antioxidants & Redox Signaling·Kamal F Badr, Tania E Abi-Antoun
Apr 19, 2005·Methods and Findings in Experimental and Clinical Pharmacology·D SinghK Chopra
Jun 18, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David L Mattson, Carla J Meister
Nov 4, 2005·Medicine·Giorgia MelliDavid R Cornblath
Nov 25, 2005·Current Medicinal Chemistry·Brandon J Reeder, Michael T Wilson
May 29, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P VlahovićV Stefanović
Sep 8, 2007·Antioxidants & Redox Signaling·Cheng LiRoland Stocker
Aug 16, 2008·Renal Failure·Sedat UstundagBora Demirkan
Aug 19, 2008·Antioxidants & Redox Signaling·Shane R ThomasGrant R Drummond
Sep 20, 2008·Nephron. Experimental Nephrology·Jay L KoynerPatrick T Murray
Feb 13, 2009·Clinical and Translational Science·Vishal S VaidyaJoseph V Bonventre
May 7, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Manuela SchneiderMarcus Conrad
Jul 3, 2009·The New England Journal of Medicine·Xavier BoschJosep M Grau

❮ Previous
Next ❯

Citations

Jul 8, 2017·Nutrients·Joanne M Dennis, Paul K Witting
Aug 29, 2019·Nature Reviews. Nephrology·Kristof Van AvondtSacha Zeerleder
Apr 4, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marco FiorentinoJohn A Kellum
Oct 22, 2020·International Journal of Molecular Sciences·Mary El KazziPaul K Witting
Jul 30, 2020·Archives of Biochemistry and Biophysics·Yuyang LiuBelal Chami
Nov 27, 2019·Kidney Diseases·Nayara Panizo GonzálezCarlos Hernando Domingo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis