PMID: 8963727May 1, 1996Paper

Cosupplementation with coenzyme Q prevents the prooxidant effect of alpha-tocopherol and increases the resistance of LDL to transition metal-dependent oxidation initiation

Arteriosclerosis, Thrombosis, and Vascular Biology
S R ThomasR Stocker

Abstract

There is considerable interest in the ability of antioxidant supplementation, in particular with vitamin E, to attenuate LDL oxidation, a process implicated in atherogenesis. Since vitamin E can also promote LDL lipid peroxidation, we investigated the effects of supplementation with vitamin E alone or in combination with coenzyme Q on the early stages of the oxidation of isolated LDL. Isolated LDL was obtained from healthy subjects before and after in vitro enrichment with vitamin E (D-alpha-tocopherol, alpha-TOH) or dietary supplementation with D-alpha-TOH (1 g/d) and/or coenzyme Q (100 mg/d). LDL oxidation initiation was assessed by measurement of the consumption of alpha-TOH and cholesteryl esters containing polyunsaturated fatty acids and the accumulation of cholesteryl ester hydroperoxides during incubation of LDL in the transition metal-containing Ham's F-10 medium in the absence and presence of human monocyte-derived macrophages (MDMs). Native LDL contained 8.5 +/- 2 molecules of alpha-TOH and 0.5 to 0.8 molecules of ubiquinol-10 (CoQ10H2, the reduced form of coenzyme Q) per lipoprotein particle. Incubation of this LDL in Ham's F-10 medium resulted in a time-dependent loss of alpha-TOH with concomitant stoichiometric con...Continue Reading

References

Jan 1, 1977·Annual Review of Biochemistry·J L Goldstein, M S Brown
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S D CushingA M Fogelman
Jan 1, 1991·The American Journal of Clinical Nutrition·H EsterbauerG Waeg
Jan 1, 1991·Journal of Medicinal Chemistry·S J MaoW A Van Sickle
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R StockerB Frei
Jan 1, 1990·Free Radical Biology & Medicine·U P SteinbrecherM Lougheed
Jan 15, 1990·The Biochemical Journal·W JessupD S Leake
Apr 6, 1989·The New England Journal of Medicine·D SteinbergJ L Witztum
Nov 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·A DaughertyG Schonfeld
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T KitaC Kawai
Aug 1, 1985·Journal of Leukocyte Biology·M K CathcartG M Chisolm
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·U P SteinbrecherD Steinberg
Mar 17, 1995·The Journal of Biological Chemistry·V W BowryR Stocker
Jul 6, 1994·Biochimica Et Biophysica Acta·Y YoshidaE Niki
Apr 14, 1994·The New England Journal of Medicine·UNKNOWN Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·D L TribbleR M Krauss
May 20, 1993·The New England Journal of Medicine·M J StampferW C Willett
May 20, 1993·The New England Journal of Medicine·E B RimmW C Willett

❮ Previous
Next ❯

Citations

Jul 23, 1999·BioFactors·S R ThomasR Stocker
Jan 6, 2000·Archives of Biochemistry and Biophysics·A D de Grey
Jul 3, 2013·Environmental Science and Pollution Research International·Pan GuoYahua Chen
May 24, 2008·Biochemical Pharmacology·L GilleW Gregor
May 24, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Michael V MilesAmadeo J Pesce
Oct 27, 2001·Molecular Aspects of Medicine·H J Forman, M Torres
Jan 1, 1997·Molecular Aspects of Medicine·H NohlK Staniek
Aug 18, 2000·Free Radical Biology & Medicine·S R Thomas, R Stocker
Oct 18, 2000·Free Radical Biology & Medicine·P K WittingR Stocker
Nov 4, 1998·Free Radical Biology & Medicine·H NohlA V Kozlov
Dec 22, 1999·The Proceedings of the Nutrition Society·M Chopra, D I Thurnham
Aug 19, 2008·Antioxidants & Redox Signaling·Shane R ThomasGrant R Drummond
Jul 17, 2004·QJM : Monthly Journal of the Association of Physicians·G T Chew, G F Watts
Mar 17, 2001·Journal of Clinical Pathology·I S Young, J V Woodside
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·J NeuzilR Stocker
Oct 17, 2015·Nutrition and Cancer·Geir Bjørklund
Jun 18, 2016·Oxidative Medicine and Cellular Longevity·Alexey V LokhmatikovArmen Y Mulkidjanian
Jul 2, 2005·Analytical Biochemistry·Anna PastoreFiorella Piemonte
Mar 11, 2000·Free Radical Research·L P van de VijverG van Poppel
Sep 15, 1998·Free Radical Research·N Noguchi, E Niki
Feb 15, 2011·Critical Care Medicine·David A BrealeyMarius Terblanche
Jan 15, 2002·The Journal of Biological Chemistry·Carlos Santos-OcañaCatherine F Clarke
Jan 5, 2000·Artificial Organs·B Kirschbaum
May 30, 2002·Biological Chemistry·Freya Q SchaferGarry R Buettner

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.