Cotinine excretion as a predictor of peak flow variability

American Journal of Respiratory and Critical Care Medicine
J KuehrW Lehnert

Abstract

Environmental tobacco smoke (ETS) is suspected to be an important risk factor for bronchial hyperresponsiveness. In order to test the effect of ETS, we measured expiratory flow rates and urine cotinine excretion (UCE) within a narrow time window in two consecutive years. Maternal smoking habits and medical history were ascertained by standardized questionnaires. The percentage ratio of the amplitude over the mean (AVAM) of the diurnal peak flow rates of children (complete values from at least five consecutive days) was calculated as an indicator of bronchial responsiveness. The association of UCE and log10AVAM was analyzed by multiple linear regression. Complete data were available for a sample of 417 children. The median of UCE in children of parents who smoked (3.2 ng/mg and 2.9 ng/mg creatinine, Surveys 1 and 2, respectively) was higher than the median in children of nonsmoking parents (0 ng/mg in both surveys). With increasing UCE the log10AVAM rose in the first and second surveys, as well as in the longitudinal analysis (p = 0.003). This association, however, showed up only in boys (p = 0.0001) and not in girls (p = 0.31). Our data suggest that there is a need both for further analysis of the gender difference and for more...Continue Reading

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Citations

Dec 9, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Joshua A LawsonAmbikaipakan Senthilselvan
Jun 8, 2011·International Journal of Emergency Medicine·Beth C BockRaymond S Niaura
Sep 3, 2005·Treatments in Respiratory Medicine·Kai-Håkon Carlsen, Karin C Lødrup Carlsen
Feb 19, 2008·Paediatric Respiratory Reviews·Kai-Håkon Carlsen, Karin Cecilie Lødrup Carlsen
Apr 14, 2000·Clinics in Chest Medicine·J P Joad
Aug 7, 1999·Primary Care·B E MitchellM H Alexander
Dec 23, 2003·Clinical Pediatrics·Elizabeth L McQuaidBelinda Borrelli

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