Cotransplantation of allogeneic mesenchymal and hematopoietic stem cells in children with aplastic anemia

Pediatrics
Hengxiang WangZikuan Guo

Abstract

We report here the preliminary results of allogeneic hematopoietic stem cell transplantation with mesenchymal stem cells (MSCs) for 6 cases of severe aplastic anemia. The patients ranged in age from 3 to 16 years, and the median time from diagnosis to transplantation was 32 months (range: 3-156 months). The conditioning regimens consisted of fludarabine, cyclophosphamide, and antithymocyte globulin with or without busulfan. Graft-versus-host disease (GvHD) was prevented by the administration of cyclosporine A, methotrexate, and mycophenolate mofetil, with or without anti-CD25 monoclonal antibody. The grafts were granulocyte colony-stimulating factor-mobilized bone marrow and peripheral blood from HLA antigen-haploidentical donors (3 cases) or peripheral blood only from unrelated HLA antigen-identical donors (3 cases). MSCs were intravenously injected at a median dose of 1.43 × 10(6)/kg (range: 0.85-2.5 × 10(6)/kg). The mean time for neutrophil and platelet recovery was 12.3 and 13.8 days, respectively. Acute GvHD grade I and II developed in 2 cases, and no chronic GvHD was documented. All patients were alive and transfusion independent at a median follow-up of 15 months (range: 6-29 months). Our report suggests that cotransplan...Continue Reading

Citations

Nov 19, 2013·Pediatric Clinics of North America·Helge D HartungMonica Bessler
Nov 3, 2015·Archives of Medical Research·Guadalupe R Fajardo-OrduñaJuan J Montesinos
May 1, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mina RizkDavid S Allan
Jan 13, 2018·World Journal of Stem Cells·Larisa BroglieJeffrey A Medin
Nov 30, 2019·Frontiers in Endocrinology·Babak ArjmandBagher Larijani
Aug 6, 2020·International Journal of Molecular Sciences·Bruno FattizzoWilma Barcellini
Nov 11, 2019·Emerging Topics in Life Sciences·Adam M VogelTara L Deans

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