Abstract
We report here the preliminary results of allogeneic hematopoietic stem cell transplantation with mesenchymal stem cells (MSCs) for 6 cases of severe aplastic anemia. The patients ranged in age from 3 to 16 years, and the median time from diagnosis to transplantation was 32 months (range: 3-156 months). The conditioning regimens consisted of fludarabine, cyclophosphamide, and antithymocyte globulin with or without busulfan. Graft-versus-host disease (GvHD) was prevented by the administration of cyclosporine A, methotrexate, and mycophenolate mofetil, with or without anti-CD25 monoclonal antibody. The grafts were granulocyte colony-stimulating factor-mobilized bone marrow and peripheral blood from HLA antigen-haploidentical donors (3 cases) or peripheral blood only from unrelated HLA antigen-identical donors (3 cases). MSCs were intravenously injected at a median dose of 1.43 × 10(6)/kg (range: 0.85-2.5 × 10(6)/kg). The mean time for neutrophil and platelet recovery was 12.3 and 13.8 days, respectively. Acute GvHD grade I and II developed in 2 cases, and no chronic GvHD was documented. All patients were alive and transfusion independent at a median follow-up of 15 months (range: 6-29 months). Our report suggests that cotransplan...Continue Reading
Citations
Nov 23, 2013·International Journal of Hematology·Yuewen FuYongping Song
Apr 15, 2014·Haematologica·Clara BuenoPablo Menendez
Feb 4, 2014·Transplantation·Zhu XishanRen Jun
Nov 19, 2013·Pediatric Clinics of North America·Helge D HartungMonica Bessler
Nov 3, 2015·Archives of Medical Research·Guadalupe R Fajardo-OrduñaJuan J Montesinos
Nov 20, 2014·Cytotechnology·Lixin XuXiaoxiong Wu
Mar 20, 2014·Pediatric Transplantation·Yang JunZhou Xuan
Sep 28, 2013·Fetal and Pediatric Pathology·Eman Refaat El-MahgoubSomaia Mohammed Mousa
May 1, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mina RizkDavid S Allan
Jan 10, 2017·Bone Marrow Transplantation·Z LiuS Wang
Jan 13, 2018·World Journal of Stem Cells·Larisa BroglieJeffrey A Medin
Sep 20, 2018·Journal of Cellular Biochemistry·Shu DengShengyun Lin
Apr 21, 2018·Transplantation·Yonghua LiYang Xiao
Mar 2, 2018·European Journal of Medical Research·Lixin XuXiaoxiong Wu
Jun 18, 2019·Biotechnology Progress·Yu PanSa Cai
Nov 30, 2019·Frontiers in Endocrinology·Babak ArjmandBagher Larijani
Jan 1, 2017·Stem Cells International·Guadalupe R Fajardo-OrduñaJuan J Montesinos
Sep 27, 2020·Stem Cells Translational Medicine·Li DingHeng Zhu
Aug 6, 2020·International Journal of Molecular Sciences·Bruno FattizzoWilma Barcellini
Feb 6, 2021·Stem Cell Research & Therapy·Ruonan LiJun Shi
Nov 11, 2019·Emerging Topics in Life Sciences·Adam M VogelTara L Deans