Abstract
This study aimed to investigate the effects of aspirin (acetyl salicylic acid [ASA]) combined with fluconazole (FCA), itraconazole (ITR), or voriconazole (VRC) on Candida albicans under planktonic and biofilm conditions. A total of 39 clinical C. albicans strains were used to perform the in vitro drug sensitivity assay under different conditions using the M27-A4 broth microdilution method. The minimal inhibitory concentrations (MICs) and fractional inhibitory concentration index (FICI) values were calculated. C. albicans ZY23 was chosen for the further analyses. Under planktonic conditions, the half maximal MIC (MIC50) values of FCA, ITR, and VRC were 64-0.5 μg/mL, 32-0.0625 μg/mL, and 16-0.125 μg/mL, respectively, when applied, whereas in combination with ASA, the values decreased to 32-0.25 μg/mL, 8-0.0313 μg/mL, and 8-0.0313 μg/mL, respectively. Under biofilm conditions, FCA, ITR, or VRC alone showed MIC50 values of 128-8 μg/mL, 32-4 μg/mL, and 32-0.5 μg/mL, whereas in combination with ASA the values were decreased to 32-0.5 μg/mL, 16-0.5 μg/mL, and 8-0.0625 μg/mL, respectively. Analysis of the FICI showed that the sensitization rate of ASA to FCA, ITR, and FCA under planktonic conditions was 43.59%, whereas the sensitizatio...Continue Reading
References
Dec 1, 1995·Antimicrobial Agents and Chemotherapy·E M ScottR M McCrory
Mar 25, 1998·Journal of Medical Microbiology·S P HawserL J Douglas
Aug 31, 2000·Journal of Medical Microbiology·C Pina-VazP A Mårdh
Apr 9, 2001·Infection and Immunity·M C NoverrG B Huffnagle
Apr 28, 2001·FEMS Microbiology Letters·R DevaS Nigam
Jun 14, 2003·The Journal of Antimicrobial Chemotherapy·F C Odds
Dec 25, 2003·Antimicrobial Agents and Chemotherapy·Mohammed A S Alem, L Julia Douglas
Oct 24, 2006·Current Opinion in Microbiology·Jill R Blankenship, Aaron P Mitchell
Mar 7, 2012·Antimicrobial Agents and Chemotherapy·Yabin ZhouJihui Jia
Jun 6, 2013·Mycoses·Naiara C SilvaAmanda L T Dias
Nov 13, 2013·Microbiology and Immunology·Takashi TamuraKoichi Makimura
Feb 11, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J Guinea
Oct 8, 2014·The Journal of Antimicrobial Chemotherapy·Aspasia KatragkouThomas J Walsh
Mar 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Kaitlin F MitchellDavid R Andes
Mar 27, 2015·Infectious Disorders Drug Targets·Umme HaniAtul Shrivastava
Apr 23, 2015·Acta biochimica Polonica·Karolina GołąbekAndrzej Wiczkowski
Jul 2, 2015·Pathogens·Freshta Akbari, Birthe Veno Kjellerup
Jun 2, 2016·Antimicrobial Agents and Chemotherapy·Adepemi O OgundejiOlihile M Sebolai
Sep 21, 2016·Journal of Microbiological Methods·Yulong TanBerit Schneider-Stickler
Feb 6, 2017·PloS One·Dae Jin KimSuhng Wook Kim
Mar 18, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Lulu ZhangYuan-Ying Jiang
May 10, 2017·BMC Infectious Diseases·Jinjian FuLijun Jiang
May 12, 2017·PloS One·Francisco Madariaga-VenegasAlfredo Molina-Berríos
Jan 6, 2018·The Journal of Antimicrobial Chemotherapy·Frederic LamothThierry Calandra
Feb 13, 2018·Experimental and Therapeutic Medicine·Wenli FengWen Cen
Apr 2, 2018·Journal de mycologie médicale·J KrólM Bartoszewicz
Dec 5, 2018·BMC Microbiology·Shengyan ChenXin Wei
Jan 9, 2019·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Ce ShiMingjie Xiang
Jun 5, 2019·Deutsches Ärzteblatt International·Marie von Lilienfeld-ToalOliver Kurzai
Sep 5, 2019·Central European Journal of Urology·Márió GajdácsKatalin Burián
Nov 11, 2019·Letters in Applied Microbiology·Wenli FengYan Ma
Dec 19, 2019·Current Medical Mycology·Fatemeh AhangarkaniHamid Badali
Dec 22, 2019·Antibiotics·Márió Gajdács, Gabriella Spengler
Nov 27, 2020·Journal of Global Antimicrobial Resistance·Wenli FengHuan Ning
Apr 2, 2021·Infection and Drug Resistance·Seyyed Askhan Senobar TahaeiMárió Gajdács