Cotrifazid--an agent against malaria

Chemotherapy
E FreerksenA R Kholowa

Abstract

Following the brief information on a new malaria treatment with the fixed multiple combination Cotrifazid (rifampicin+isoniazid+sulfamethoxazole+trimethoprim) in Chemotherapy [1995;41:396-398], very good results are reported for the treatment of 61 patients with various forms of malaria. The tolerance was found to be good. Some relevant fundamental considerations (chemoresistance, synergism/antagonism, fixed multiple combination, switching from monotherapy to combination therapy) and the implementation of the principle of a "multidisease therapy' are discussed.

Citations

May 17, 2001·Antimicrobial Agents and Chemotherapy·B PradinesD Parzy
Mar 11, 2005·Expert Opinion on Therapeutic Targets·Jochen Wiesner, Frank Seeber
Aug 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Diana FontinhaMiguel Prudêncio

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