PMID: 9435040Jan 1, 1997Paper

Cotrimoxazole is effective as primary prophylaxis for toxoplasmic encephalitis in HIV-infected patients: a case control study

Scandinavian Journal of Infectious Diseases
H M WeigelJ T van der Meer

Abstract

In a case-control study, prophylaxis with cotrimoxazole for toxoplasmic encephalitis (TE) in HIV-infected patients was evaluated. Cotrimoxazole had been given as PCP prophylaxis. 20 patients with TE were identified and 72 matching control cases were found. All patients had IgG-antibodies to Toxoplasma gondii and CD4+ T-cell counts < or = 100/microliter. The use and duration of cotrimoxazole prophylaxis were recorded. It was found that among the patients with TE, none had used cotrimoxazole for > 70% of the observation time, and that the 1-y incidence was 0% in the control group vs. 41% in those patients without sufficient cotrimoxazole use. The conclusion is that cotrimoxazole is effective as primary prophylaxis for TE, even in a dose of 480 mg daily.

References

Dec 3, 1992·The New England Journal of Medicine·S B Porter, M A Sande
Aug 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B J Luft, J S Remington
Jan 1, 1988·The Journal of Infectious Diseases·B J Luft, J S Remington
Apr 1, 1994·AIDS·E OksenhendlerJ P Aboulker
Oct 1, 1993·Neurology·M F Falangola, C K Petito
May 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J VeenstraR A Coutinho

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Citations

Oct 12, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S AbgrallUNKNOWN Clinical Epidemiology Group of the French Hospital Database on HIV
Feb 26, 2010·British Journal of Haematology·E Graham Davies, Adrian J Thrasher
Mar 10, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·M MaynartUNKNOWN SIDAK Study Group
Feb 13, 2010·Journal of Medical Microbiology·Rafael T MesquitaVera L Pereira-Chioccola
Dec 1, 2001·Scandinavian Journal of Infectious Diseases·C RabaudUNKNOWN Delta trial group

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