Cotton rat (Sigmodon hispidus) develops metabolic disorders associated with visceral adipose inflammation and fatty pancreas without obesity

Cell and Tissue Research
Teppei NakamuraYasuhiro Kon

Abstract

Obesity induces metabolic disorders such as type 2 diabetes, hypertension, and cardiovascular diseases and has become a global health concern. Recent studies imply that fat accumulation in nonadipose tissue correlates with metabolic disorders. However, there are no suitable animal models to evaluate this phenomenon. This study investigated the characteristics of metabolic disorders found in cotton rat (Sigmodon hispidus). Blood biochemical examinations revealed that cotton rats, predominantly males, developed hyperinsulinemia, hyperglycemia, and dyslipidemia when fed a normal diet. The islets increased in size through β-cell hyperplasia, which was associated with serum insulin level in both sexes, strongly indicating insulin resistance. In male cotton rats, oxidative stress was observed in β cells, and macrophage infiltration into the visceral white adipose tissue was reported, both of which were associated with serum insulin level without visceral obesity. In contrast, female cotton rats developed hyperinsulinemia without histopathological changes that were reported in males. Adipocytes were found to be accumulated in the pancreas but not in the liver of both sexes during aging. Pancreatic fat accumulation was associated with ...Continue Reading

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Citations

Sep 20, 2019·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Nihar ShahOmer Endashaw
Oct 20, 2019·Histochemistry and Cell Biology·Osamu IchiiYasuhiro Kon
Nov 17, 2020·Frontiers in Physiology·Tsolmon ChuluunbaatarYasuhiro Kon
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Md Rashedul IslamYasuhiro Kon
Dec 28, 2021·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Daisuke KondohYasuhiro Kon

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

H3A
BZ
hybrid Cell Count

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