Cough augmentation in Duchenne muscular dystrophy

American Journal of Physical Medicine & Rehabilitation
Yuka IshikawaRoseanna Jackson-Parekh

Abstract

The purpose of this work was to compare the relative importance of deep lung insufflation with the abdominal thrust and their combination in augmenting cough peak flows (CPF). Unassisted CPF and CPF assisted by air stacking to deep lung volumes (CPFair), assisted by abdominal thrusts (CPFthrust), and assisted by both air stacking and abdominal thrusts (aCPF) were measured for 61 patients with Duchenne muscular dystrophy (DMD). Overall, mean unassisted CPF were 138 +/- 70 liters/min, CPFthrust were 204 +/- 75 liters/min, CPFair were 236 +/- 68 liters/min, and aCPF were 302 +/- 78 liters/min. The differences between each were statistically significant (P < 0.0001). Thus, air stacking was significantly more effective than abdominal thrust in increasing CPF, but the combination was the most effective. The CPF of the quartile of patients with the lowest unassisted CPF were also significantly (P < or = 0.04) more augmented by air stacking and thrusting than for the milder quartiles of patients. Thus, the greatest improvements in CPF were for patients with the weakest coughs.

Associated Clinical Trials

Nov 13, 2013·Uwe Mellies

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Citations

Apr 22, 2010·American Journal of Physical Medicine & Rehabilitation·Michele VitaccaMiguel R Gonçalves
Sep 14, 2012·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Stuart ClearyWendy Johnston
Dec 15, 2010·Neuromuscular Disorders : NMD·Yuka IshikawaRyoji Minami
Aug 5, 2009·Archives of Physical Medicine and Rehabilitation·Sang Chul LeeSang Ha Song
May 21, 2017·Archives of Physical Medicine and Rehabilitation·Antonio SarmentoArmele Dornelas de Andrade
Nov 9, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Nicole SheersDavid J Berlowitz
Sep 4, 2020·Archives of Physical Medicine and Rehabilitation·Rachel O'SullivanRebecca Hemming
Jun 25, 2021·Disability and Rehabilitation·Z E DavidsonUNKNOWN Clinical Practice Guideline Development Group
Jun 15, 2021·Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace·Vijay HaddaAntonio Esquinas
Jul 31, 2021·BMJ Open Respiratory Research·Phoebe E NaughtonSherri L Katz
Oct 3, 2018·Pediatrics·Daniel W SheehanLisa F Wolfe

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