Cough in pediatric patients receiving angiotensin-converting enzyme inhibitor therapy or angiotensin receptor blocker therapy in randomized controlled trials.

Clinical Pharmacology and Therapeutics
C M Baker-SmithP B Smith

Abstract

The incidence of cough in children receiving antihypertension therapy with angiotensin-converting enzyme inhibitors (ACEis) or angiotensin receptor blockers (ARBs) is unknown. We analyzed patient-level data from eight randomized trials for the treatment of pediatric hypertension, six of them involving ACEis and two involving ARBs. The incidence of cough in children receiving ACEis (reported cough, 3.2%) was similar to that in children receiving ARBs (reported cough, 1.8%) (P = 0.34). Reports of cough were lower in children than in adults.

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Citations

Feb 22, 2014·Advanced Drug Delivery Reviews·M A TurnerUNKNOWN Global Research in Paediatrics
Aug 8, 2014·Pediatric Annals·Rigoberto Acosta, Sami L Bahna
Mar 13, 2012·Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine·Mary M StephensLisa Maxwell
Aug 17, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Brian R Stotter, Michael A Ferguson
Jan 19, 2011·Journal of Cardiovascular Pharmacology·Joseph T Flynn
Sep 17, 2014·Expert Review of Clinical Pharmacology·Daniel B HawcuttMark A Turner
Apr 7, 2016·Current Hypertension Reports·Rachita S DhullTej K Mattoo
Nov 5, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nida Siddiqi, Ibrahim F Shatat
Apr 2, 2020·Physiological Research·J-S ShimA H Morice

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