Coughing, mucus accumulation, airway obstruction, and airway inflammation in control horses and horses affected with recurrent airway obstruction

American Journal of Veterinary Research
N E RobinsonF J Derksen

Abstract

To investigate relationships between cough frequency and mucus accumulation, airway obstruction, and airway inflammation and to determine effects of dexamethasone on coughing and mucus score. 13 horses with recurrent airway obstruction (RAO) and 6 control horses. 6 RAO-affected and 6 control horses were stabled for 3 days. Coughing was counted for 4 hours before and on each day horses were stabled. Before and on day 3 of stabling, tracheal mucus accumulation was scored, airway obstruction was assessed via maximal change in pleural pressure (deltaPpl(max)), and airway inflammation was evaluated by use of cytologic examination of bronchoalveolar lavage fluid (BALF). Effects of dexamethasone (0.1 mg/kg, IV, q 24 h for 7 days) were determined in 12 RAO-affected horses. To assess frequency, coughing had to be counted for 1 hour. In RAO-affected horses, stabling was associated with increases in cough frequency, mucus score, and deltaPpl(max). Control horses coughed transiently when first stabled. In RAO-affected horses, coughing was correlated with deltaPpl(max), mucus score, and airway inflammation and was a sensitive and specific indicator of deltaPpl(max) > 6 cm H2O, mucus score > 1.0, and > 100 neutrophils/microL and > 20% neutro...Continue Reading

References

Jul 1, 1995·The European Respiratory Journal·J G Widdicombe
Feb 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P G GibsonJ Dolovich
Feb 1, 1994·American Journal of Respiratory and Critical Care Medicine·L P BouletM Laviolette
May 1, 1995·The British Veterinary Journal·N E RobinsonV A Buechner-Maxwell
Feb 3, 1998·American Journal of Respiratory Cell and Molecular Biology·J A HotchkissJ R Harkema
Nov 6, 1998·Journal of Applied Physiology·A XiangS Hasegawa
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J TodtJ L Curtis
Oct 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S M FairbairnF M Cunningham
Feb 13, 2001·Pulmonary Pharmacology & Therapeutics·A Di FrancoP L Paggiaro
Jan 31, 2002·Equine Veterinary Journal·N E RobinsonF J Derksen

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Citations

Feb 19, 2009·Occupational Medicine·Melissa R MazanAndrew M Hoffman
Aug 10, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Mathilde LeclereJean-Pierre Lavoie
Sep 15, 2009·Journal of Veterinary Internal Medicine·N E RobinsonF J Derksen
Jan 26, 2016·Journal of Veterinary Internal Medicine·L L CouëtilE A Richard
Oct 30, 2015·Respirology : Official Journal of the Asian Pacific Society of Respirology·Barbara PerezGabriel Morán
May 20, 2011·Equine Veterinary Journal·V GerberN E Robinson
Oct 3, 2014·Journal of Veterinary Internal Medicine·K M IvesterN J Zimmerman
Mar 16, 2017·Equine Veterinary Journal·L CalzettaM G Matera
Jun 23, 2006·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Jean A HallJohn W Schlipf
Dec 20, 2017·Veterinary Pathology·Claudenir R FerrariCyprianna E Swiderski
Feb 3, 2018·Equine Veterinary Journal·L CalzettaM G Matera
Sep 18, 2018·Journal of Veterinary Internal Medicine·Kathleen M IvesterGeorge E Moore
Oct 9, 2018·Journal of Veterinary Internal Medicine·Stephanie BondR Scott Pirie
Jun 5, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Karin Aharonson-RazBaljit Singh
Jul 16, 2004·Equine Veterinary Journal·C J CornelisseF J Derksen
Oct 11, 2019·Current Allergy and Asthma Reports·M Katie SheatsJill A Poole
Sep 10, 2020·Frontiers in Veterinary Science·Laurent CouetilCyprianna Swiderski
Jul 27, 2006·Equine Veterinary Journal·N E RobinsonF J Derksen
Jun 5, 2021·Journal of Veterinary Internal Medicine·Sophie Mainguy-Seers, Jean-Pierre Lavoie

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