PMID: 26899579Feb 24, 2016Paper

Could Better Phenotyping Small Vessel Disease Provide New Insights into Alzheimer Disease and Improve Clinical Trial Outcomes?

Current Alzheimer Research
Michael Marnane, G Y R Hsiung

Abstract

Alzheimer Disease (AD) is the most common primary cause of dementia with a burgeoning epidemic as life expectancy and general medical care improve worldwide. Recent data from pathologic studies has shown that the cooccurrence of other neurodegenerative and vascular pathologies is in fact the rule rather than the exception. In late onset AD, cerebral small vessel disease (SVD) is almost invariably co-existent to a greater or lesser extent and is known to promote cognitive deterioration. Previous observational studies and clinical trials have largely sought to divide dementia based on predominant neurodegenerative or vascular mechanisms. Given the high degree of overlap, findings from such studies may be difficult to interpret and apply to population cohorts. Additionally opportunities may be lost for uncovering novel interventions that target interactions between co-existent vascular and neurodegenerative pathologies. In the current review, we consider potential pathophysiologic mechanisms through which SVD may be associated with and promote AD pathology. In particular we explore shared environmental and genetic associations and how these may converge via neuroinflammatory pathways potentially providing novel therapeutic targets...Continue Reading

Citations

May 31, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·David S Liebeskind
Sep 30, 2017·Nature Reviews. Neurology·Jun WangYan-Jiang Wang
Nov 28, 2020·International Journal of Stroke : Official Journal of the International Stroke Society·Dearbhla M Kelly, Peter M Rothwell
Dec 16, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Bessie C StammAdam M Brickman

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