Could exercise metabolomics pave the way for gymnomimetics?

Science Translational Medicine
Megan F BurkeDaniel J Rader

Abstract

Regular physical activity and especially aerobic exercise are associated with reduced risk of disease and enhanced longevity, but the molecular mechanisms of these health benefits remain obscure. A comprehensive metabolomic approach was used to characterize the changes in blood levels of >200 metabolites upon vigorous exercise and identified two dozen that changed substantially. One, niacinamide, is intimately related to the metabolism of nicotinamide adenine dinucleotide (NAD(+)) and its reduced form NADH, which is in turn linked with exercise capacity as well as health status. Intensive investigation of metabolic changes with exercise could lead to pharmacological attempts to mimic the beneficial effects of exercise, an approach we term "gymnomimetics."

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Citations

Dec 1, 2012·Analytical and Bioanalytical Chemistry·Adam ClouseSylvia Daunert
Sep 15, 2012·The Journal of Nutritional Biochemistry·Adrian B HodgsonDoris M Jacobs
Aug 16, 2016·Cell·Carlos López-OtínGuido Kroemer
Apr 27, 2012·American Journal of Physiology. Endocrinology and Metabolism·Kishorchandra Gohil, George A Brooks
Aug 28, 2021·International Journal of Molecular Sciences·Francesca LatinoFrancesco Fischetti

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