Could reduced cerebrospinal fluid (csf) galanin contribute to restricted eating in anorexia nervosa?

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
G K FrankC W McConaha

Abstract

Galanin (GAL) and gamma amino butyric acid (GABA) are orexigenic neuropeptides that could contribute to the pathogenesis of anorexia nervosa (AN). To avoid the confounding effects of the ill state, we studied women who were recovered (> 1 year, normal weight, and regular menstrual cycles, no binging or purging) from AN (REC AN) and matched healthy control women (NC). CSF GAL was reduced in REC AN (64.4 +/- 8.6 pg/ml) compared to NC (72.0 +/- 11.6 pg/ml; p <.05), GABA was similar between groups. In the brain, GAL stimulates appetite and fat consumption. These data raise the question of whether alterations in brain GAL activity plays a role in clinical symptoms in AN, such as food restriction and fat avoidance.

Citations

Feb 3, 2007·Eating and Weight Disorders : EWD·C L Birmingham, S Gritzner
Sep 15, 2004·Biological Psychiatry·Margaret AltemusDeveroux Ferguson
Jun 20, 2014·European Eating Disorders Review : the Journal of the Eating Disorders Association·Alfonso TortorellaPalmiero Monteleone
Mar 11, 2005·Expert Opinion on Therapeutic Targets·James L RoerigKristine J Steffen
Jun 30, 2006·Biological Psychiatry·Kirsty M O BrownJohn E Blundell

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