Could schizoaffective disorder, schizophrenia and bipolar I disorder be distinguishable using cognitive profiles?

Psychiatry Research
Chih-Ken ChenLiang-Jen Wang

Abstract

This study seeks to determine whether the cognition profiles of patients with schizoaffective disorder (SAD), schizophrenia and bipolar I disorder (BD) are distinguishable. A total of 227 participants, comprising 88 healthy control subjects, 50 patients with SAD, 48 patients with schizophrenia and 41 patients with BD, were recruited. The participants' cognitive functions were evaluated using the Brief Assessment of Cognition in Schizophrenia (BACS). A discriminant functions analysis (DFA) was conducted to determine whether using cognitive performance can be used to distinguish these participant groups. Relative to healthy control subjects, patients with SAD, schizophrenia and BD exhibited significant deficits in all cognitive domains (verbal memory, working memory, motor speed, verbal fluency, attention and processing speed, executive function and a composite BACS score). Among the three patient groups, the schizophrenia group exhibited particularly impaired motor speed, and the BD group performed best in attention, processing speed, executive function and the composite BACS score. The classification accuracy rates of patients with SAD, schizophrenia and BD in the DFA model were 38%, 47.9% and 46.3%, respectively. These finding...Continue Reading

Citations

Mar 19, 2021·Revista colombiana de psiquiatría·Stephen Baena-OquendoCarlos López-Jaramillo
Jul 17, 2021·European Archives of Psychiatry and Clinical Neuroscience·Manuel J CuestaUNKNOWN SegPEPs Group
Jun 10, 2020·Neuropsychobiology·Alejandra Mondragón-MayaRicardo Saracco-Álvarez

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