Could Somatostatin Enhance the Outcomes of Chemotherapeutic Treatment in SCLC?

Journal of Cancer
Kalliopi DomvriKonstantinos Zarogoulidis

Abstract

Somatostatin is a peptide with a potent and broad antisecretory action, which makes it an invaluable drug target for the pharmacological management of pituitary adenomas and neuroendocrine tumors. Furthermore, somatostatin (SST) receptors (SSTR1, 2A and B, 3, 4 and 5) belong to the G protein coupled receptor family and are overexpressed in tumors. Since, human small-cell lung cancer overexpresses somatostatin receptors (STTR), they could be legitimate targets for treating SCLC.The aim of this study was the evaluation of cytotoxicity of somatostatin in combination with several anticancer drugs in HTB-175 cell line (Small Cell Lung Cancer Cell line that expresses neuron specific enolase). Docetaxel, Paclitaxel, Carboplatin, Cisplatin, Etoposide, Gemzar, Navelbine, Fluorouracil, Farmorubicin are the chemotherapeutic drugs that we used for the combination before and after adding somatostatin in SCLC cell culture. HTB-175 cell line was purchased from ATCC LGC Standards.At indicated time-point, 48h after the combination, cell viability and apoptosis were measured with Annexin V staining by flow cytometry. Flow cytometry showed that Docetaxel, Paclitaxel, Gemzar and Cisplatin induced apoptosis more when they were added before somatost...Continue Reading

Citations

Apr 14, 2016·Seminars in Nuclear Medicine·Alfredo TartaroneMichele Aieta
Oct 27, 2017·Expert Opinion on Pharmacotherapy·Gherardo MazziottiAndrea Giustina
May 14, 2019·Technology in Cancer Research & Treatment·Efimia BoutsikouKonstantinos Zarogoulidis

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