PMID: 11323083Apr 27, 2001Paper

Could the 5-HT1B receptor inverse agonism affect learning consolidation?

Neuroscience and Biobehavioral Reviews
Alfredo Meneses

Abstract

Diverse evidence indicates that, the 5-HT system might play a role in learning and memory, since it occurs in brain areas mediating such processes and 5-HT drugs modulate them. Hence in this work, in order to explore further 5-HT involvement on learning and memory 5-HT1B receptors' role is investigated. Evidence indicates that SB-224289 (a 5-HT1B receptor inverse agonist) post-training injection facilitated learning consolidation in an associative autoshaping learning task, this effect was partially reversed by GR 127935 (a 5-HT1B/1D receptor antagonist), but unaffected by MDL 100907 (a 5-HT2A receptor antagonist) or ketanserin (a 5-HT1D/2A/7 receptor antagonist) at low doses. Moreover, SB-224289 antagonized the learning deficit produced by TFMPP (a 5-HT1A/1B/1D/2A/2C receptor agonist), GR 46611 (a 5-HT1A/1B/1D receptor agonist), mCPP (a 5-HT2A/2C/3/7 receptor agonist/antagonist) or GR 127935 (at low dose). SB-224289 did not alter the 8-OH-DPAT (a 5-HT1A/7 receptor agonist) learning facilitatory effect. SB-224289 eliminated the deficit learning produced by the anticholinergic muscarinic scopolamine or the glutamatergic antagonist dizocilpine. Administration of both, GR 127935 (5mg/kg) plus ketanserin (0.01 mg/kg) did not modify...Continue Reading

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Citations

Feb 6, 2013·Pharmacology, Biochemistry, and Behavior·Arne MørkConnie Sanchez
May 11, 2016·Journal of Alzheimer's Disease : JAD·Walid TajeddinnDag Aarsland
May 12, 2005·Physiology & Behavior·B J HoplightJ F Neumaier
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Mar 28, 2017·Reviews in the Neurosciences·Alfredo Meneses
Nov 22, 2013·Reviews in the Neurosciences·Alfredo Meneses
Mar 4, 2020·International Journal of Molecular Sciences·Julien Bacqué-CazenavePhilippe De Deurwaerdère
Jan 21, 2020·Neuropharmacology·Philippe De DeurwaerdèreGiuseppe Di Giovanni
Nov 11, 2020·Neuroscience and Biobehavioral Reviews·Salar VaseghiMohammad-Reza Zarrindast
Apr 3, 2020·Current Topics in Medicinal Chemistry·Shigeto Hirayama, Hideaki Fujii

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