Could the skewness and kurtosis texture parameters of lesions obtained from pretreatment Ga-68 DOTA-TATE PET/CT images predict receptor radionuclide therapy response in patients with gastroenteropancreatic neuroendocrine tumors?

Nuclear Medicine Communications
Hasan ÖnnerAhmet Tutuş

Abstract

In our study, tumor heterogeneity was evaluated using the parameters skewness and kurtosis on pretreatment Ga-68 DOTA-TATE PET/CT to assess therapy responses of lesions in patients with gastroenteropancreatic neuroendocrine tumors (GEP NETs) treated with peptide receptor radionuclide therapy (PRRT). We retrospectively studied the texture analysis with relatively simple first-order parameters skewness and kurtosis on pretreatment Ga-68 DOTA-TATE PET/CT from 22 patients (eight females, 14 males; with a mean age: 54 ± 11 years) with GEP NETs who were treated with 2-6 therapy cycles of Lu-177 DOTA-TATE. A total of 326 lesions of 22 patients were evaluated in terms of treatment response by Ga-68 DOTA-TATE PET/CT examination performed before and after treatment. Receiver-operating characteristic (ROC) curves were generated to assess skewness and kurtosis to discriminate between responder and nonresponder lesions. A total of 326 lesions of 22 patients were evaluated and 137 lesions responded partially or completely to the treatment, 189 lesions did not respond to treatment, remained stable or progressed. The skewness and kurtosis values of the lesions which did not respond to the PRRT were significantly higher than those with response...Continue Reading

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Citations

Dec 11, 2020·Diagnostics·Diletta CalabròValentina Ambrosini
Apr 10, 2021·European Journal of Nuclear Medicine and Molecular Imaging·C BezziM Picchio
Jun 1, 2021·PET Clinics·Rebecca K S WongPatrick Veit-Haibach
Jul 27, 2021·Revista española de medicina nuclear e imagen molecular·H ÖnnerM I E Karanis
Oct 14, 2021·Journal of Applied Clinical Medical Physics·Kenneth J NicholsChristopher J Palestro

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