Coumarin Ameliorates Impaired Bone Turnover by Inhibiting the Formation of Advanced Glycation End Products in Diabetic Osteoblasts and Osteoclasts.

Biomolecules
Eun-Jung LeeYoung-Hee Kang

Abstract

Accumulating evidence demonstrates that the risk of osteoporotic fractures increases in patients with diabetes mellitus. Thus, diabetes-induced bone fragility has recently been recognized as a diabetic complication. As the fracture risk is independent of the reduction in bone mineral density, deterioration in bone quality may be the main cause of bone fragility. Coumarin exists naturally in many plants as phenylpropanoids and is present in tonka beans in significantly high concentrations. This study investigated whether coumarin ameliorated the impaired bone turnover and remodeling under diabetic condition. The in vitro study employed murine macrophage Raw 264.7 cells differentiated to multinucleated osteoclasts with receptor activator of nuclear factor-κΒ ligand (RANKL) in the presence of 33 mM glucose and 1-20 μM coumarin for five days. In addition, osteoblastic MC3T3-E1 cells were exposed to 33 mM glucose for up to 21 days in the presence of 1-20 μM coumarin. High glucose diminished tartrate-resistant acid phosphatase activity and bone resorption in RANKL-differentiated osteoclasts, accompanying a reduction of cathepsin K induction and actin ring formation. In contrast, coumarin reversed the defective osteoclastogenesis in d...Continue Reading

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Citations

Jan 21, 2021·Biomolecules·Barbara RomanoRaffaele Capasso
Jan 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dmitry DeryabinGalimzhan Duskaev
Jan 23, 2021·International Journal of Molecular Sciences·Andreea-Mariana NegrescuAnisoara Cimpean
Jul 3, 2021·International Journal of Molecular Sciences·Hideki KitauraItaru Mizoguchi

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Methods Mentioned

BETA
light microscopy
electrophoresis

Software Mentioned

Statistical Analysis Systems

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