PMID: 6160841May 1, 1980Paper

Council Lecture. Drusen and their relationship to senile macular degeneration

Australian Journal of Ophthalmology
S H Sarks

Abstract

This study is based on the clinico-pathological examination of 512 eyes. As senile macular degeneration developed drusen appeared to alter in consistency and become more fluid. This resulted in a spectrum of clinical appearances classified as hard, semisolid, soft or serous, and regressing. Histologically the hyaline contents of the drusen changed to a pale-staining amorphous material which electron microscopy showed to consist of vesicles. This membranous debris first appeared beneath the pigment epithelium in normal aged eyes but its later accumulation led to a widespread shallow separation of the basement membrane. The softening of drusen was most evident in group IV in which subretinal neovascularization was first detected. At this stage the retinal pigment epithelium also showed its greatest proliferative activity and the formation of abnormal basement membrane material.

References

Feb 1, 1977·The British Journal of Ophthalmology·Z GregorI H Chisholm
May 1, 1976·The British Journal of Ophthalmology·S H Sarks
Jan 1, 1972·Transactions of the American Ophthalmological Society·J D Gass
Sep 1, 1973·Archives of Ophthalmology·J D Gass
Jun 1, 1971·American Journal of Ophthalmology·T G FarkasD Archer

❮ Previous
Next ❯

Citations

Feb 28, 1983·Documenta Ophthalmologica. Advances in Ophthalmology·J A Oosterhuis
Jan 1, 1985·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·P L PenfoldS H Sarks
Jan 1, 1986·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·K U Löffler, W R Lee
Apr 1, 1987·Biological Trace Element Research·B J Panessa-WarrenC Kaplan
Aug 19, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Peter GourasMartha Neuringer
May 1, 1985·Ophthalmology·M O Tso
Sep 1, 1986·Ophthalmology·W R Green, D J Wilson
Apr 5, 2001·Progress in Retinal and Eye Research·P L PenfoldJ M Provis
Jan 27, 1999·Progress in Retinal and Eye Research·R GuymerA Bird
Feb 16, 2000·Progress in Retinal and Eye Research·J CaiD P Jones
Jan 1, 1988·Eye·J P SarksM C Killingsworth
Jan 1, 1994·Eye·J P SarksM C Killingsworth
Jan 1, 1995·Eye·C J KennedyI J Constable
Jan 25, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Gennady LandaPatricia M T Garcia
Apr 1, 1990·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·P G Swann, J E Lovie-Kitchin
Mar 19, 2005·The British Journal of Ophthalmology·A Remky, A E Elsner
Dec 1, 1981·The British Journal of Ophthalmology·A HoskinA C Bird
Jun 1, 1981·The British Journal of Ophthalmology·A HoskinK Sehmi
Nov 1, 1989·The British Journal of Ophthalmology·M F RainesC D Short
Dec 1, 1993·The British Journal of Ophthalmology·J N KirkpatrickJ V Forrester
Feb 1, 1994·The British Journal of Ophthalmology·A ManivannanJ V Forrester
Oct 1, 1995·The British Journal of Ophthalmology·W S KarwatowskiD L Easty
Dec 6, 2001·The British Journal of Ophthalmology·A RemkyO Arend
Apr 24, 2001·The British Journal of Ophthalmology·B MoldowH Lund-Andersen
Feb 25, 2003·The British Journal of Ophthalmology·S AbugreenU Chakravarthy
Jul 31, 1998·Postgraduate Medical Journal·J G O'Shea
Oct 3, 2009·Journal of Lipid Research·Christine A CurcioMartin Rudolf
Apr 30, 2010·PloS One·Lan WangChristine A Curcio
Dec 24, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Haris KokotasMichael B Petersen
Dec 3, 2013·Progress in Retinal and Eye Research·Nicole T M SaksensCarel B Hoyng
Oct 15, 1987·American Journal of Ophthalmology·D A NewsomeJ R Hassell
May 15, 1986·American Journal of Ophthalmology·F el BabaZ C de la Cruz
Aug 1, 1995·American Journal of Ophthalmology·L L RitterS C Jensen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.