PMID: 9171973May 1, 1997Paper

Countercurrent transfer of 125I-LHRH in the perihypophyseal cavernous sinus-carotid rete vascular complex, demonstrated on isolated pig heads perfused with autologous blood

Domestic Animal Endocrinology
W J GrzegorzewskiT Krzymowski

Abstract

The objective of the study was to determine whether the local permeability of luteinizing hormone-releasing hormone (LHRH) from the venous blood of the perihypophyseal cavernous sinus into the arterial blood of the carotid rete, supplying the brain and hypophysis in gilts, depends on the day of the estrous cycle, as well as to determine whether this transfer exists when LH concentration in the blood is reduced (the experimental short-loop negative feedback for LH secretion after estradiol injection in ovariectomized gilts). Experiments were conducted on isolated gilt heads with necks, on chosen days of the estrous cycle (n = 40), and on previously ovariectomized gilts treated with estradiol benzoate (EB) (n = 5) or corn oil (n = 3). After exsanguination, the gilt heads with necks were disarticulated and about 30-45 min later were supplied with autologous, oxygenated, and heated blood at a stable blood flow and pressure through the left carotid artery for 30 min. 125I-LHRH was infused into both cavernous sinuses through the cannulated angularis oculi veins for 5 min. After 125I-LHRH infusion, radiolabeled LHRH was found (P < 0.001) in arterial blood taken from the carotid rete through the open right carotid artery in all animals...Continue Reading

References

Feb 28, 1978·Biochemical and Biophysical Research Communications·P J Fraker, J C Speck
Aug 1, 1963·Journal of Reproduction and Fertility·H W HAWKH F RIGHTER

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Citations

Sep 18, 2008·Bulletin of Mathematical Biology·Yue-Xian Li, Anmar Khadra
Apr 23, 2008·Biology Letters·G Mitchell, A Lust
Dec 24, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·N Einer-Jensen, Rhf Hunter
Sep 26, 2015·Journal of Theoretical Biology·Haley D O'Brien, Jason Bourke
Apr 17, 2016·Annals of Nuclear Medicine·Masoumeh ZoghiSaeed Ramezanpour
Aug 16, 2018·Journal of Labelled Compounds & Radiopharmaceuticals·Masoumeh ZoghiSaaed Rajabifar
Apr 30, 2019·Journal of Labelled Compounds & Radiopharmaceuticals·Masoumeh ZoghiFariba Johari Daha
Apr 13, 2020·Chemical Biology & Drug Design·Arezou Masteri FarahaniMostafa Erfani
Jun 21, 2020·Anti-cancer Agents in Medicinal Chemistry·Arezou Masteri FarahaniMostafa Erfani

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