Countermeasures to Coronavirus Disease 2019: Are Immunomodulators Rational Treatment Options-A Critical Review of the Evidence.

Open Forum Infectious Diseases
Daniel B ChastainSharmon P Osae

Abstract

Severe acute respiratory syndrome coronavirus 2 is associated with higher concentrations of proinflammatory cytokines that lead to lung damage, respiratory failure, and resultant increased mortality. Immunomodulatory therapy has the potential to inhibit cytokines and quell the immune dysregulation. Controversial data found improved oxygenation after treatment with tocilizumab, an interleukin-6 inhibitor, sparking a wave of interest and resultant clinical trials evaluating immunomodulatory therapies. The purpose of this article is to assess potential proinflammatory targets and review the safety and efficacy of immunomodulatory therapies in managing patients with acute respiratory distress syndrome associated with coronavirus disease 2019.

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Citations

Oct 29, 2020·Current Transplantation Reports·Mario Fernández-Ruiz, José María Aguado
Feb 27, 2021·Expert Opinion on Pharmacotherapy·María Del Mar GutierrezPere Domingo

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Methods Mentioned

BETA
biopsies
bronchoalveolar lavage

Clinical Trials Mentioned

NCT04317092
NCT04331795
NCT04332094
NCT04320615
NCT04332913
NCT04306705
NCT04310228
NCT04333914
NCT04331808
NCT04315480

Software Mentioned

iSearch
Google Scholar

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