Abstract
We used microdialysis to distinguish the effects of hyperinsulinemia and hypoglycemia on glucose, gluconeogenic substrate, and catecholamine levels in adipose and muscle extracellular fluid (ECF). Ten lean humans (six males and four females) were studied during baseline and hyperinsulinemic (3 mU x kg-1 x min-1 for 3 h) euglycemia (5.0 mmol/l) and hypoglycemia (2.8 mmol/l). In muscle and adipose, basal ECF glucose was lower (muscle, 3.5 +/- 0.2 mmol/l; adipose tissue, 3.3 +/- 0.2 mmol/l) and lactate was higher (muscle, 2.2 +/- 0.2 mmol/l; adipose, 1.5 +/- 0.3 mmol/l) than respective plasma values (glucose, 4.9 +/- 0.1 mmol/l; lactate, 0.7 +/- 0.1 mmol/l), whereas alanine was higher in muscle ECF (379 +/- 22 micromol/l) than adipose tissue (306 +/- 22 micromol/l) and plasma (273 +/- 33 micromol/l). Plasma catecholamines (unchanged during euglycemia) rose during hypoglycemia with epinephrine, increasing approximately fivefold more than norepinephrine. In contrast, the hypoglycemia-induced increments in muscle dialysate norepinephrine and epinephrine were similar, suggesting local generation of norepinephrine. Compared with euglycemia, hypoglycemia produced a greater increase in lactate and a smaller reduction in alanine in muscle...Continue Reading
Citations
Jan 18, 2005·Journal of Neurology·Marie GirotDidier Leys
Jul 10, 2003·Life Sciences·Merja HaaparantaOlof Solin
Nov 15, 2001·Pharmacology & Therapeutics·G Eisenhofer
Aug 17, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·G AlbertsF Boomsma
Sep 13, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·B E de Galan, J B Hoekstra
Nov 13, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·W V TamborlaneE Boland
Jun 6, 1998·The New England Journal of Medicine·T W JonesW V Tamborlane
Mar 4, 2005·Treatments in Endocrinology·Samuel Dagogo-Jack
Dec 20, 2007·Clinical Endocrinology·Alia MunirJohn Newell-Price
Jul 16, 2004·Metabolism: Clinical and Experimental·Volker MerlBernd Schultes
Mar 12, 2005·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Yehia Y Mishriki
Nov 19, 2008·European Journal of Pharmacology·Taishi YoshidaToshihiko Fujiwara
Jul 22, 2011·American Journal of Physiology. Cell Physiology·S LivermoreC A Nurse
Sep 11, 2012·The Journal of Clinical Endocrinology and Metabolism·A J FaheyP A Fournier
Apr 8, 2003·The Journal of Clinical Endocrinology and Metabolism·Staffan EnokssonRobert S Sherwin
Mar 14, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Walid M Abi-SaabRobert S Sherwin
Mar 2, 2002·Diabetes·Robert P HoffmanBradley G Phillips
Apr 12, 2018·Diabetes Technology & Therapeutics·Vanessa MoscardóPaolo Rossetti
Oct 12, 1999·The American Journal of Physiology·T W LamerisA J Veld
Mar 11, 2004·American Journal of Physiology. Endocrinology and Metabolism·Luiz Carlos C NavegantesIsis C Kettelhut
Apr 6, 2000·Journal of Applied Physiology·V StichF Crampes
Jul 27, 2000·American Journal of Physiology. Endocrinology and Metabolism·B StallknechtH Galbo
Nov 25, 2005·Diabetes Care·Nicola N Zammitt, Brian M Frier
Nov 10, 2005·American Journal of Physiology. Endocrinology and Metabolism·Elisabet BørsheimRobert R Wolfe
Feb 10, 1999·The American Journal of Physiology·L SchauppP Wach
Aug 6, 2003·American Journal of Physiology. Endocrinology and Metabolism·Vladimir StichMichel Berlan
Mar 10, 1999·The American Journal of Physiology·K Zierler
Mar 1, 2003·Diabetes Care·Rakesh AminDavid B Dunger
Apr 30, 2002·Diabetes Care·Teresa P MonsodWilliam V Tamborlane
Aug 28, 2001·Diabetes·E CersosimoJ Ferretti
Nov 14, 1998·The American Journal of Physiology·D S ParamoreP E Cryer