Counterregulatory responses: sustained-release isosorbide-5-mononitrate versus transdermal nitroglycerin

Journal of Cardiovascular Pharmacology
J D Parker

Abstract

Therapy with nitroglycerin is associated with the development of counterregulatory responses. This investigation documents the counterregulatory responses to once daily sustained-release isosorbide-5-mononitrate, contrasting them with those observed during continuous transdermal nitroglycerin. Twenty male volunteers were studied in a single-blind, parallel comparison of sustained-release isosorbide-5-mononitrate versus continuous transdermal nitroglycerin. This was a 5-day in-hospital study. Standing systolic blood pressure, heart rate, hematocrit, plasma catecholamines, and plasma renin activity were assessed at baseline (day 1), during 3 days of nitrate therapy (days 2-4), and on day 5, when no therapy was given. The administration of both transdermal nitroglycerin and isosorbide-5-mononitrate was associated with a decrease in systolic blood pressure and an increase in heart rate. There was loss of the systolic blood pressure effects within 48 h in both groups. The effect on heart rate was maintained over time and was greater in the isosorbide-5-mononitrate group. Nitrate therapy caused no change in plasma catecholamine concentrations and only modest changes in plasma renin activity. In both groups, there was a decrease in he...Continue Reading

References

Sep 1, 1992·Journal of the American College of Cardiology·J D ParkerJ O Parker
Nov 1, 1991·European Heart Journal·J Abrams
Oct 1, 1990·Journal of the American College of Cardiology·M Packer
Jan 1, 1990·European Journal of Clinical Pharmacology·F WagnerE Jähnchen
Mar 15, 1989·Journal of the American College of Cardiology·H DeMots, S P Glasser
Sep 24, 1987·The New England Journal of Medicine·M PackerM Yushak
Nov 1, 1988·Biopharmaceutics & Drug Disposition·D K YuD H Giesing
Jun 25, 1987·The New England Journal of Medicine·J O Parker
Jun 4, 1987·The New England Journal of Medicine·J O ParkerG Moe
Jul 1, 1983·Journal of the American College of Cardiology·J J DalalJ O Parker
Jul 1, 1984·The American Journal of Cardiology·N ReichekM S Sutton
Nov 1, 1983·Circulation·J O ParkerJ A Stone
Jan 1, 1982·European Journal of Clinical Pharmacology·P MüllerA Gérardin
Dec 1, 1993·The American Journal of Cardiology·S G ChrysantR Casareto

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Citations

Jan 5, 2002·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Armel StockisDaniela Acerbi
Jul 19, 2013·European Heart Journal·Thomas MünzelTommaso Gori
Nov 26, 2003·European Journal of Clinical Investigation·F Iachini BellisariiR De Caterina
Feb 28, 2006·Journal of Cardiac Failure· Heart Failure Society Of America
Jun 2, 2015·Expert Opinion on Pharmacotherapy·Cocco GiuseppeIselin Hans-Ulrich
Oct 31, 2002·Circulation·Tommaso Gori, John D Parker
Nov 6, 2002·Circulation·Tommaso Gori, John D Parker
Jan 31, 2009·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Tommaso Gori, Andreas Daiber

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