PMID: 8976164Dec 1, 1996Paper

Counterselection against D mu is mediated through immunoglobulin (Ig)alpha-Igbeta

The Journal of Experimental Medicine
S GongM C Nussenzweig

Abstract

The pre-B cell receptor is a key checkpoint regulator in developing B cells. Early events that are controlled by the pre-B cell receptor include positive selection for cells express membrane immunoglobulin heavy chains and negative selection against cells expressing truncated immunoglobulins that lack a complete variable region (D mu). Positive selection is known to be mediated by membrane immunoglobulin heavy chains through Ig alpha-Ig beta, whereas the mechanism for counterselection against D mu has not been determined. We have examined the role of the Ig alpha-Ig beta signal transducers in counterselection against D mu using mice that lack Ig beta. We found that D mu expression is not selected against in developing B cells in Ig beta mutant mice. Thus, the molecular mechanism for counterselection against D mu in pre-B cells resembles positive selection in that it requires interaction between mD mu and Ig alpha-Ig beta.

References

Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T E CostaM C Nussenzweig
Mar 6, 1992·Cell·P MombaertsV E Papaioannou
Jun 1, 1992·The Journal of Experimental Medicine·T E CostaM C Nussenzweig
Feb 1, 1991·International Immunology·J NomuraN Sakaguchi
May 1, 1991·The Journal of Experimental Medicine·R R HardyK Hayakawa
Sep 20, 1991·Cell·A Rolink, F Melchers
Apr 14, 1983·Nature·S Tonegawa
Sep 1, 1993·The Journal of Experimental Medicine·M SanchezM Nussenzweig
Apr 21, 1995·Science·F PapavasiliouM C Nussenzweig
Jul 1, 1995·The Journal of Experimental Medicine·H T PetrieS Mazel
Jul 1, 1994·Current Biology : CB·A EhlichK Rajewsky
Nov 1, 1985·Immunology Today·M Kaartinen, O Mäkelä

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Citations

Feb 6, 2002·Springer Seminars in Immunopathology·E M Fuentes-Pananá, J G Monroe
Apr 1, 1997·Current Opinion in Immunology·F PapavasiliouM C Nussenzweig
Mar 28, 1998·The Journal of Experimental Medicine·U C TornbergD Holmberg
Jun 8, 1999·Annual Review of Immunology·T Kurosaki
Aug 24, 2010·Immunological Reviews·Markus WernerHassan Jumaa
Mar 23, 2001·Nature Immunology·E MeffreM C Nussenzweig
Jul 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Roberta PelandaMichael Reth
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shibin MaRunqing Lu
Sep 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T FangC A Roman

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