Counting Mitoses With Digital Pathology in Breast Phyllodes Tumors

Archives of Pathology & Laboratory Medicine
Zi Long ChowPuay Hoon Tan

Abstract

Mitotic count is an important histologic criterion for grading and prognostication in phyllodes tumors (PTs). Counting mitoses is a routine practice for pathologists evaluating neoplasms, but different microscopes, variable field selection, and areas have led to possible misclassification. To determine whether 10 high-power fields (HPFs) or whole slide mitotic counts correlated better with PT clinicopathologic parameters using digital pathology (DP). We also aimed to find out whether this study might serve as a basis for an artificial intelligence (AI) protocol to count mitosis. Representative slides were chosen from 93 cases of PTs diagnosed between 2014 and 2015. The slides were scanned and viewed with DP. Mitotic counting was conducted on the whole slide image, before choosing 10 HPFs and demarcating the tumor area in DP. Values of mitoses per millimeter squared were used to compare results between 10 HPFs and the whole slide. Correlations with clinicopathologic parameters were conducted. Both whole slide counting of mitoses and 10 HPFs had similar statistically significant correlation coefficients with grade, stromal atypia, and stromal hypercellularity. Neither whole slide mitotic counts nor mitoses per 10 HPFs showed stat...Continue Reading

References

Nov 6, 2009·Archives of Pathology & Laboratory Medicine·John S MeyerHans Peter Graf
Nov 4, 2011·Journal of Clinical Pathology·Puay Hoon TanUNKNOWN Phyllodes Tumour Network Singapore
Jan 16, 2016·Histopathology·Benjamin Y TanPuay Hoon Tan
May 4, 2016·Journal of Pathology Informatics·Michael C Montalto
Aug 27, 2016·Journal of Pathology Informatics·Andrew Janowczyk, Anant Madabhushi
Feb 17, 2017·Biomedical Engineering Online·Michael Bonert, Angela J Tate

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Citations

Feb 13, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Fei DengLanjing Zhang
Jun 4, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ian A CreeRichard A Scolyer

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