Country-wide medical records infer increased allergy risk of gastric acid inhibition

Nature Communications
Galateja JordakievaErika Jensen-Jarolim

Abstract

Gastric acid suppression promotes allergy in mechanistic animal experiments and observational human studies, but whether gastric acid inhibitors increase allergy incidence at a population level remains uncharacterized. Here we aim to assess the use of anti-allergic medication following prescription of gastric acid inhibitors. We analyze data from health insurance records covering 97% of Austrian population between 2009 and 2013 on prescriptions of gastric acid inhibitors, anti-allergic drugs, or other commonly prescribed (lipid-modifying and antihypertensive) drugs as controls. Here we show that rate ratios for anti-allergic following gastric acid-inhibiting drug prescriptions are 1.96 (95%CI:1.95-1.97) and 3.07 (95%-CI:2.89-3.27) in an overall and regional Austrian dataset. These findings are more prominent in women and occur for all assessed gastric acid-inhibiting substances. Rate ratios increase from 1.47 (95%CI:1.45-1.49) in subjects <20 years, to 5.20 (95%-CI:5.15-5.25) in > 60 year olds. We report an epidemiologic relationship between gastric acid-suppression and development of allergic symptoms.

References

Sep 19, 2003·The Journal of Allergy and Clinical Immunology·Eva UntersmayrErika Jensen-Jarolim
Jan 11, 2005·The American Journal of Clinical Nutrition·Isabella SchöllErika Jensen-Jarolim
Jan 27, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Eva UntersmayrErika Jensen-Jarolim
Aug 1, 2006·Immunology Letters·Noemi BakosErika Jensen-Jarolim
Jan 18, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Isabella SchöllHarald Renz
Sep 14, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R BrunnerI Pali-Schöll
Apr 9, 2008·Allergy·E Jensen-Jarolim, E Untersmayr
Jun 10, 2008·The Journal of Allergy and Clinical Immunology·Eva Untersmayr, Erika Jensen-Jarolim
Oct 13, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A B RiemerE Jensen-Jarolim
Mar 11, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·I Pali-SchöllE Jensen-Jarolim
Dec 3, 2010·Allergy·I Pali-Schöll, E Jensen-Jarolim
Mar 23, 2011·The Journal of Allergy and Clinical Immunology·Rachel M McLoughlin, Kingston H G Mills
Apr 20, 2011·Allergology International : Official Journal of the Japanese Society of Allergology·Ken AraeToshiharu Nakajima
Mar 27, 2012·Alimentary Pharmacology & Therapeutics·A B T AndersenH T Sørensen
Jul 11, 2012·Therapeutic Advances in Gastroenterology·Joel J HeidelbaughPaul C Walker
Feb 19, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E RamírezS Quirce
Nov 28, 2015·Alimentary Pharmacology & Therapeutics·L Cea SorianoL A García-Rodríguez
Dec 15, 2015·Gut·Floris ImhannAlexandra Zhernakova
Jan 1, 2016·Gut·Matthew A JacksonClaire J Steves
Nov 5, 2016·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Susanne C DiesnerEva Untersmayr
Nov 22, 2016·World Journal of Gastrointestinal Pharmacology and Therapeutics·Mark SafeUsha Krishnan
Jan 14, 2017·The Journal of Allergy and Clinical Immunology·Rebecca E DevineBright I Nwaru
May 23, 2017·Gastroenterology·Michael F VaeziColin W Howden
Nov 7, 2017·Journal of Gastroenterology and Hepatology·Tsuyoshi MishiroYoshikazu Kinoshita
Jan 18, 2018·The Journal of Allergy and Clinical Immunology. in Practice·Jose J LagunaMaria J Torres
Jan 27, 2018·Journal of Clinical Biochemistry and Nutrition·Tomohisa TakagiYoshito Itoh
Feb 7, 2018·Mayo Clinic Proceedings·Avinash K NehraVandana Nehra
Mar 30, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Deborah S LeuthardPål Johansen
May 8, 2018·Nature Communications

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Citations

Feb 20, 2020·Seminars in Immunopathology·Karin HufnaglErika Jensen-Jarolim
Jul 30, 2020·International Journal of Molecular Sciences·Margherita Di CostanzoGiacomo Biasucci
Aug 10, 2020·Nature Communications·Erika Jensen-JarolimGalateja Jordakieva
Aug 10, 2020·Nature Communications·Kewin Tien Ho Siah
Nov 7, 2019·MMW Fortschritte der Medizin·H S Füeßl
Apr 14, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H CetinE Stögmann
Jun 12, 2020·Current Allergy and Asthma Reports·Eric A PasmanCade M Nylund
Sep 2, 2020·Current Opinion in Gastroenterology·Mitchell L Schubert
Dec 17, 2020·Zentralblatt für Chirurgie·Angela Horvath, Vanessa Stadlbauer
Jun 3, 2020·The Journal of Allergy and Clinical Immunology·Franziska Roth-WalterErika Jensen-Jarolim
Mar 4, 2021·Nutrients·Nazanin SamadiEva Untersmayr
Aug 25, 2021·Pharmacotherapy·Tammy H CummingsS Scott Sutton

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