Coupled biomechanical response of the cornea assessed by non-contact tonometry. A simulation study

PloS One
Miguel Á Ariza-GraciaBegoña Calvo

Abstract

The mechanical response of the cornea subjected to a non-contact air-jet tonometry diagnostic test represents an interplay between its geometry, the corneal material behavior and the loading. The objective is to study this interplay to better understand and interpret the results obtained with a non-contact tonometry test. A patient-specific finite element model of a healthy eye, accounting for the load free configuration, was used. The corneal tissue was modeled as an anisotropic hyperelastic material with two preferential directions. Three different sets of parameters within the human experimental range obtained from inflation tests were considered. The influence of the IOP was studied by considering four pressure levels (10-28 mmHg) whereas the influence of corneal thickness was studied by inducing a uniform variation (300-600 microns). A Computer Fluid Dynamics (CFD) air-jet simulation determined pressure loading exerted on the anterior corneal surface. The maximum apex displacement showed a linear variation with IOP for all materials examined. On the contrary, the maximum apex displacement followed a cubic relation with corneal thickness. In addition, a significant sensitivity of the apical displacement to the corneal stiff...Continue Reading

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Citations

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Software Mentioned

POPCORN
ANSYS
ABAQUS
ParaView
CorVis ST

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