Coupled changes in hippocampal structure and cognitive ability in later life

Brain and Behavior
Devasuda AnblaganJoanna M Wardlaw

Abstract

The hippocampus plays an important role in cognitive abilities which often decline with advancing age. In a longitudinal study of community-dwelling adults, we investigated whether there were coupled changes in hippocampal structure and verbal memory, working memory, and processing speed between the ages of 73 (N = 655) and 76 years (N = 469). Hippocampal structure was indexed by hippocampal volume, hippocampal volume as a percentage of intracranial volume (H_ICV), fractional anisotropy (FA), mean diffusivity (MD), and longitudinal relaxation time (T1). Mean levels of hippocampal volume, H_ICV, FA, T1, and all three cognitive abilities domains decreased, whereas MD increased, from age 73 to 76. At baseline, higher hippocampal volume was associated with better working memory and verbal memory, but none of these correlations survived correction for multiple comparisons. Higher FA, lower MD, and lower T1 at baseline were associated with better cognitive abilities in all three domains; only the correlation between baseline hippocampal MD and T1, and change in the three cognitive domains, survived correction for multiple comparisons. Individuals with higher hippocampal MD at age 73 experienced a greater decline in all three cognitiv...Continue Reading

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Citations

Feb 2, 2019·Scientific Reports·Claudia Metzler-BaddeleyRoland J Baddeley
Apr 18, 2020·The European Respiratory Journal·David LawiDan Adler
Dec 22, 2019·Brain Structure & Function·L JänckeS Merillat
Apr 9, 2020·Frontiers in Aging Neuroscience·Dayana HayekDaria Antonenko
Jun 14, 2019·Reviews in the Neurosciences·Jessica OschwaldSusan Mérillat
Aug 27, 2019·Multivariate Behavioral Research·Eduardo EstradaEmilio Ferrer
Jul 15, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hongjian PuJun Chen
Oct 3, 2021·Hippocampus·Kevin Grant SolarChristian Beaulieu

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