PMID: 15783348Mar 24, 2005Paper

Coupled dynamics of voltage and calcium in paced cardiac cells

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Yohannes ShiferawAlain Karma

Abstract

We investigate numerically and analytically the coupled dynamics of transmembrane voltage and intracellular calcium cycling in paced cardiac cells using a detailed physiological model, and its reduction to a three-dimensional discrete map. The results provide a theoretical framework to interpret various experimentally observed modes of instability ranging from electromechanically concordant and discordant alternans to quasiperiodic oscillations of voltage and calcium.

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Related Concepts

Nerve Impulses
Cardiac Arrhythmia
Oscillators, Biological
Calcium
In Silico
Feedback - System Communication
Cardiac Conduction System
Pulse Rate
Resting Potentials
Calcium Sparks

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