We investigate numerically and analytically the coupled dynamics of transmembrane voltage and intracellular calcium cycling in paced cardiac cells using a detailed physiological model, and its reduction to a three-dimensional discrete map. The results provide a theoretical framework to interpret various experimentally observed modes of instability ranging from electromechanically concordant and discordant alternans to quasiperiodic oscillations of voltage and calcium.
Electrophysiological alternans and restitution during acute regional ischaemia in myocardium of anaesthetized pig
Rapid ionic modifications during the aequorin-detected calcium transient in a skinned canine cardiac Purkinje cell
The influence of boot weight on the energy expenditure of men walking on a treadmill and climbing steps
A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes
Premature beats elicit a phase reversal of mechanoelectrical alternans in cat ventricular myocytes. A possible mechanism for reentrant arrhythmias
Relationship between L-type Ca2+ current and unitary sarcoplasmic reticulum Ca2+ release events in rat ventricular myocytes
Potentiation of fractional sarcoplasmic reticulum calcium release by total and free intra-sarcoplasmic reticulum calcium concentration
Regulation of Ca2+ and electrical alternans in cardiac myocytes: role of CAMKII and repolarizing currents
Targeted SERCA2a gene expression identifies molecular mechanism and therapeutic target for arrhythmogenic cardiac alternans
Oscillation in cycle length induces transient discordant and steady-state concordant alternans in the heart
Calcium-activated chloride current determines action potential morphology during calcium alternans in atrial myocytes
T-tubule disruption promotes calcium alternans in failing ventricular myocytes: mechanistic insights from computational modeling
New experimental evidence for mechanism of arrhythmogenic membrane potential alternans based on balance of electrogenic I(NCX)/I(Ca) currents
The link between repolarisation alternans and ventricular arrhythmia: does the cellular phenomenon extend to the clinical problem?
Mechanisms and potential therapeutic targets for ventricular arrhythmias associated with impaired cardiac calcium cycling
Intracellular Ca alternans: coordinated regulation by sarcoplasmic reticulum release, uptake, and leak
Mechanism for action potential alternans: the interplay between L-type calcium current and transient outward current
Modifying L-type calcium current kinetics: consequences for cardiac excitation and arrhythmia dynamics
Ca2+ alternans in a cardiac myocyte model that uses moment equations to represent heterogeneous junctional SR Ca2+
Action potential morphology influences intracellular calcium handling stability and the occurrence of alternans
Effects of ganglionated plexi ablation on ventricular electrophysiological properties in normal hearts and after acute myocardial ischemia
Action potential duration dispersion and alternans in simulated heterogeneous cardiac tissue with a structural barrier
Stretch-Activated Current Can Promote or Suppress Cardiac Alternans Depending on Voltage-Calcium Interaction
Membrane potential determines calcium alternans through modulation of SR Ca2+ load and L-type Ca2+ current
Action potential duration restitution and alternans in rabbit ventricular myocytes: the key role of intracellular calcium cycling
Mechanisms underlying the formation and dynamics of subcellular calcium alternans in the intact rat heart
Coupled Iterated Map Models of Action Potential Dynamics in a One-dimensional Cable of Cardiac Cells
Period-doubling bifurcation to alternans in paced cardiac tissue: crossover from smooth to border-collision characteristics
Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat
Characterizing the contribution of voltage- and calcium-dependent coupling to action potential stability: implications for repolarization alternans
β-Adrenergic Inhibition Prevents Action Potential and Calcium Handling Changes during Regional Myocardial Ischemia
Impaired Sarcoplasmic Reticulum Calcium Uptake and Release Promote Electromechanically and Spatially Discordant Alternans: A Computational Study
A model for cooperative gating of L-type Ca2+ channels and its effects on cardiac alternans dynamics
Dual regulation by subcellular calcium heterogeneity and heart rate variability on cardiac electromechanical dynamics
Delayed global feedback in the genesis and stability of spatiotemporal excitation patterns in paced biological excitable media.
Multimodal on-axis platform for all-optical electrophysiology with near-infrared probes in human stem-cell-derived cardiomyocytes.
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Cardiac Conduction System
The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.