Coupled pacing reverses the effects of persistent atrial fibrillation on the left ventricle

The Annals of Thoracic Surgery
George E YanulisDon W Wallick

Abstract

Recent studies have demonstrated that ventricular rate control is a viable treatment strategy for patients in atrial fibrillation (AF). The purpose of this study was to determine whether or not the benefits of coupled pacing (ie, a proposed rate control therapy) could be used during persistent AF. Six mongrel dogs were chronically implanted with endocardial atrial and ventricular pacemaker leads and two standard dual-chamber pacemakers. With the use of two custom "Y"-lead adapters, the pacemakers were used to induce AF and to apply coupled pacing. Left ventricular end-diastolic and systolic volumes were measured by echocardiography to determine ejection fractions. Persistent AF significantly increased both ventricular rate and left ventricular dimensions. After sustained coupled pacing had been applied for 3 to 4 weeks, left ventricular volumes and contractile rate were significantly reduced and returned toward the values measured prior to the induction of persistent AF. Coupled pacing increased the ejection fraction that had been reduced by persistent AF. Coupled pacing reversed the left ventricular remodeling caused by the tachycardia resulting from AF.

References

Dec 1, 1988·Canadian Journal of Physiology and Pharmacology·R J HowardP W Armstrong
May 30, 2006·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Hirotsugu YamadaDon W Wallick

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Citations

Feb 2, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Pascal LimDon W Wallick
Jan 29, 2014·Pacing and Clinical Electrophysiology : PACE·Camille BrémontNicolas Lellouche

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