Coupled phases and combinatorial selection in fluctuating hydrothermal pools: a scenario to guide experimental approaches to the origin of cellular life

Life
Bruce Damer, D W Deamer

Abstract

Hydrothermal fields on the prebiotic Earth are candidate environments for biogenesis. We propose a model in which molecular systems driven by cycles of hydration and dehydration in such sites undergo chemical evolution in dehydrated films on mineral surfaces followed by encapsulation and combinatorial selection in a hydrated bulk phase. The dehydrated phase can consist of concentrated eutectic mixtures or multilamellar liquid crystalline matrices. Both conditions organize and concentrate potential monomers and thereby promote polymerization reactions that are driven by reduced water activity in the dehydrated phase. In the case of multilamellar lipid matrices, polymers that have been synthesized are captured in lipid vesicles upon rehydration to produce a variety of molecular systems. Each vesicle represents a protocell, an "experiment" in a natural version of combinatorial chemistry. Two kinds of selective processes can then occur. The first is a physical process in which relatively stable molecular systems will be preferentially selected. The second is a chemical process in which rare combinations of encapsulated polymers form systems capable of capturing energy and nutrients to undergo growth by catalyzed polymerization. Giv...Continue Reading

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Citations

Dec 20, 2015·Astrobiology·David W Deamer, Christos D Georgiou
Mar 13, 2016·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·Marc Tessera
Apr 5, 2016·Life·Michele Fiore, Peter Strazewski
Jul 1, 2015·Trends in Biochemical Sciences·C M Paleos
Mar 31, 2015·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·Neville J Woolf
Apr 14, 2015·Life·Pierre-Alain Monnard, Peter Walde
Apr 30, 2016·Physical Chemistry Chemical Physics : PCCP·Sankar Chatterjee
Jul 30, 2016·Artificial Life·Tim TaylorJason Yosinski
Nov 8, 2016·PLoS Computational Biology·Ye Eun Kim, Paul G Higgs
Aug 23, 2016·Scientific Reports·Sebastian HimbertMaikel C Rheinstädter
Jan 21, 2017·Life·David Deamer
Jul 7, 2017·Astrobiology·David Deamer, Bruce Damer
Jun 21, 2017·Life·Helen Greenwood Hansma
Mar 1, 2018·Astrobiology·F WestallA Brack
Jul 17, 2018·Astrobiology·Manasvi Lingam, Abraham Loeb
Jan 30, 2019·Chemical Communications : Chem Comm·Ryo MizuuchiDavid Baum
Feb 2, 2019·Astrobiology·David Ross, David Deamer
Mar 3, 2019·Life·Wim HordijkStuart A Kauffman
Apr 5, 2019·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·Kazumi YoshiyaShigenori Maruyama
Oct 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Ben K D PearceThomas K Henning
Aug 20, 2019·Astrobiology·David J Des Marais, Malcolm R Walter
May 11, 2017·Beilstein Journal of Organic Chemistry·David Deamer
Jan 23, 2020·Life·Christian Mayer
Dec 17, 2019·Astrobiology·Bruce Damer, David Deamer
Oct 24, 2019·Interface Focus·Simon DuvalWolfgang Nitschke
Mar 11, 2020·Astrobiology·Bronwyn L TeeceMartin J Van Kranendonk

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