Coupled Simulation of Hemodynamics and Vascular Growth and Remodeling in a Subject-Specific Geometry

Annals of Biomedical Engineering
Jiacheng Wu, Shawn C Shadden

Abstract

A computational framework to couple vascular growth and remodeling (G&R) with blood flow simulation in a 3D patient-specific geometry is presented. Hyperelastic and anisotropic properties are considered for the vessel wall material and a constrained mixture model is used to represent multiple constituents in the vessel wall, which was modeled as a membrane. The coupled simulation is divided into two time scales-a longer time scale for G&R and a shorter time scale for fluid dynamics simulation. G&R is simulated to evolve the boundary of the fluid domain, and fluid simulation is in turn used to generate wall shear stress and transmural pressure data that regulates G&R. To minimize required computation cost, the fluid dynamics are only simulated when G&R causes significant vascular geometric change. For demonstration, this coupled model was used to study the influence of stress-mediated growth parameters, and blood flow mechanics, on the behavior of the vascular tissue growth in a model of the infrarenal aorta derived from medical image data.

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Citations

Apr 27, 2016·Biomechanics and Modeling in Mechanobiology·Jiacheng Wu, Shawn C Shadden
May 9, 2016·Journal of Biomechanics·Calvin KuoDavid B Camarillo
Oct 23, 2019·Annals of Biomedical Engineering·Florian JolyIrene Vignon-Clementel
Aug 23, 2019·Journal of the Royal Society, Interface·Davide AmbrosiEllen Kuhl
Jun 14, 2020·Biomechanics and Modeling in Mechanobiology·Frederico S TeixeiraPaul N Watton
Nov 25, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Jiacheng WuShawn C Shadden
Mar 25, 2021·Mathematical Biosciences and Engineering : MBE·Guoyi KeWenrui Hao
Sep 25, 2017·Trends in Biotechnology·Amanda RandlesJane A Leopold

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