Coupling chemical and biological catalysis: a flexible paradigm for producing biobased chemicals

Current Opinion in Biotechnology
Thomas J SchwartzJames A Dumesic

Abstract

Advances in metabolic engineering have allowed for the development of new biological catalysts capable of selectively de-functionalizing biomass to yield platform molecules that can be upgraded to biobased chemicals using high efficiency continuous processing allowed by heterogeneous chemical catalysis. Coupling these disciplines overcomes the difficulties of selectively activating COH bonds by heterogeneous chemical catalysis and producing petroleum analogues by biological catalysis. We show that carboxylic acids, pyrones, and alcohols are highly flexible platforms that can be used to produce biobased chemicals by this approach. More generally, we suggest that molecules with three distinct functionalities may represent a practical upper limit on the extent of functionality present in the platform molecules that serve as the bridge between biological and chemical catalysis.

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Citations

Mar 16, 2017·Biotechnology and Bioengineering·Pamela B Besada-LombanaNancy A Da Silva
Mar 11, 2020·Annual Review of Chemical and Biomolecular Engineering·Jiajie Huo, Brent H Shanks
Apr 10, 2019·ChemSusChem·Brent H Shanks, Linda J Broadbelt
Oct 3, 2019·Physical Chemistry Chemical Physics : PCCP·Anand Mohan Verma, Nanda Kishore
Apr 20, 2021·Annual Review of Chemical and Biomolecular Engineering·Nick FacklerMichael Köpke
Dec 19, 2019·ACS Applied Materials & Interfaces·Benjamin GreydanusJ Will Medlin

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