Coupling mechanical tension and GTPase signaling to generate cell and tissue dynamics

Physical Biology
Cole ZmurchokLeah Edelstein-Keshet

Abstract

Regulators of the actin cytoskeleton such Rho GTPases can modulate forces developed in cells by promoting actomyosin contraction. At the same time, through mechanosensing, tension is known to affect the activity of Rho GTPases. What happens when these effects act in concert? Using a minimal model (1 GTPase coupled to a Kelvin-Voigt element), we show that two-way feedback between signaling ('RhoA') and mechanical tension (stretching) leads to a spectrum of cell behaviors, including contracted or relaxed cells, and cells that oscillate between these extremes. When such 'model cells' are connected to one another in a row or in a 2D sheet ('epithelium'), we observe waves of contraction/relaxation and GTPase activity sweeping through the tissue. The minimal model lends itself to full bifurcation analysis, and suggests a mechanism that explains behavior observed in the context of development and collective cell behavior.

References

May 1, 1980·Journal of Mathematical Biology·G OdellP Alberch
Jul 30, 1981·Developmental Biology·G M OdellB Burnside
Mar 24, 1999·The Journal of Cell Biology·C D Nobes, A Hall
Jun 22, 1999·Current Biology : CB·K RottnerJ V Small
Nov 24, 2001·Trends in Cell Biology·A J Ridley
Jul 10, 2002·The Journal of Cell Biology·Akira KatsumiMartin Alexander Schwartz
Oct 2, 2003·Current Opinion in Cell Biology·Masaki FukataKozo Kaibuchi
Oct 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Roland KaunasShu Chien
Nov 19, 2005·Science·Dennis E DischerYu-Li Wang
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kit WongHenry Bourne
Apr 12, 2006·Nature Reviews. Molecular Cell Biology·Viola Vogel, Michael Sheetz
Jun 24, 2006·Bulletin of Mathematical Biology·Athanasius F M MaréeLeah Edelstein-Keshet
Jul 26, 2006·The Journal of Cell Biology·Alexandra Van KeymeulenHenry R Bourne
Apr 26, 2007·Bulletin of Mathematical Biology·Alexandra JilkineLeah Edelstein-Keshet
Jun 15, 2007·PLoS Computational Biology·Mikiya OtsujiShinya Kuroda
Sep 11, 2007·Biophysical Journal·Benedikt SabassUlrich S Schwarz
Jan 24, 2008·Biophysical Journal·Yoichiro MoriLeah Edelstein-Keshet
Jun 16, 2009·Current Opinion in Cell Biology·Alok Tomar, David D Schlaepfer
Aug 21, 2009·Nature·Matthias MachacekGaudenz Danuser
Sep 9, 2010·Cell Communication and Signaling : CCS·Matteo Parri, Paola Chiarugi
Sep 20, 2011·Trends in Cell Biology·Christophe GuilluyKeith Burridge
Jan 6, 2012·Molecular BioSystems·Mikhail A TsyganovBoris N Kholodenko
Apr 10, 2012·Methods in Cell Biology·Maciej H SwatJames A Glazier
Aug 14, 2012·Nature Cell Biology·Mary PinesGuy Tanentzapf
Nov 6, 2012·Trends in Cell Biology·Alba Diz-MuñozOrion D Weiner
Apr 3, 2013·Journal of Cell Science·Jessica McCormackVania M M Braga
Oct 18, 2014·Physical Review Letters·Kai DierkesGuillaume Salbreux
Jan 22, 2015·Biophysical Journal·Steven M ZehnderThomas E Angelini
Jan 30, 2015·Cell Communication and Signaling : CCS·Francisco M VegaAnne J Ridley
Mar 12, 2015·The International Journal of Biochemistry & Cell Biology·Ceniz Zihni, Stephen James Terry
Mar 18, 2015·Journal of Molecular Cell Biology·Tae-Hwan KimKwang-Hyun Cho
Sep 14, 2015·Current Opinion in Cell Biology·Anne J Ridley
Oct 16, 2015·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Steven M ZehnderThomas E Angelini
Feb 28, 2016·Trends in Cell Biology·Benoit LadouxXavier Trepat
May 4, 2016·PLoS Computational Biology·Joseph H R HetmanskiPatrick T Caswell
May 11, 2016·The Journal of Cell Biology·Abhishek KumarMartin A Schwartz

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Citations

Dec 12, 2019·Molecular Biology of the Cell·Katherine M PearceSuzanne Scarlata
Sep 27, 2020·Bulletin of Mathematical Biology·Ryan J MurphyMatthew J Simpson
Feb 6, 2020·Bulletin of Mathematical Biology·Andreas ButtenschönLeah Edelstein-Keshet
Aug 28, 2020·Frontiers in Physiology·Etienne RouxThierry Couffinhal
Oct 24, 2019·Physical Review. E·Dietmar OelzZoltan Neufeld
Aug 20, 2019·Proceedings. Mathematical, Physical, and Engineering Sciences·R J MurphyM J Simpson
May 20, 2020·Scientific Reports·Hamid KhataeeZoltan Neufeld
Dec 11, 2020·PLoS Computational Biology·Andreas Buttenschön, Leah Edelstein-Keshet
Dec 29, 2020·Proceedings. Mathematical, Physical, and Engineering Sciences·Tamara A TambyahMatthew J Simpson
Dec 22, 2020·Annual Review of Condensed Matter Physics·Shiladitya BanerjeeUlrich S Schwarz
Oct 12, 2020·Current Opinion in Cell Biology·Min Wu, Jian Liu
Mar 5, 2021·Journal of Mathematical Biology·Yue LiuLeah Edelstein-Keshet
Mar 15, 2021·Biomechanics and Modeling in Mechanobiology·Patrick A LinkSeth H Weinberg
Jun 10, 2019·Acta Biomaterialia·Kiersten E ScottStephanie I Fraley
Apr 1, 2021·Physical Biology·Ryan J MurphyMatthew J Simpson
Apr 22, 2021·Physical Biology·Clinton H Durney, James J Feng
Sep 26, 2020·Biophysical Journal·Cole ZmurchokWilliam R Holmes
Aug 28, 2021·Journal of Mammary Gland Biology and Neoplasia·Gina ReyeHonor J Hugo
Sep 21, 2021·Physical Biology·Elisabeth G Rens, Leah Edelstein-Keshet

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