Coupling of ascorbate and nitric oxide dynamics in vivo in the rat hippocampus upon glutamatergic neuronal stimulation: a novel functional interplay

Brain Research Bulletin
N R FerreiraJ Laranjinha

Abstract

Ascorbate and neuronal-derived nitric oxide (NO) play regulatory roles in the brain that tare dependent on their compartmentalization and diffusion. Glutamatergic activation triggers both ascorbate fluxes toward extracellular medium and NO production. The information on the profiles of change in time and space upon glutamatergic activation is scarce and yet this knowledge is important for the understanding of ascorbate and NO functions in vivo, in particular in the case of a coupled interaction between both dynamics. NO produced upon NMDA receptor activation is a modulator of ascorbate release to the extracellular space. In this work, carbon fiber microelectrodes for simultaneous measurements of these substances in the hippocampus were used to collect information about ascorbate and NO dynamic profiles in real time. Glutamate stimulation evoked transient ascorbate and NO signals with high degree of spatial and temporal correlation between them. Combined experiments encompassing direct stimulus with NO and inhibitors of glutamate uptake and nNOS provided additional evidence supporting the modulator role of NO in the release of ascorbate to the extracellular space. The coupling between NO and ascorbate upon glutamatergic activati...Continue Reading

References

Jan 1, 1995·Annual Review of Physiology·J Garthwaite, C L Boulton
Nov 14, 1998·Brain Research·E A Kiyatkin, G V Rebec
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·D JabaudonU Gerber
Apr 27, 2000·Trends in Neurosciences·M E Rice
Jul 17, 2004·Free Radical Biology & Medicine·Yi Long MaKelly L Drew
Mar 23, 2005·Neuroscience Letters·George V RebecRobert T Kennedy
Oct 8, 2005·Korean Journal of Ophthalmology : KJO·Jae Woo Kim
Jan 24, 2007·Physiological Reviews·Pál PacherLucas Liaudet
May 18, 2007·BMC Neuroscience·Michael I Sandstrom, George V Rebec
Jul 28, 2007·Neuroscience Research·Hiroki KitauraKatsuei Shibuki
Sep 12, 2009·Cardiovascular Research·Judy M Muller-Delp
May 25, 2010·Archives of Biochemistry and Biophysics·Alessandro CortiAlfonso Pompella
Jul 19, 2011·Brain Research·Barbora PiknovaAfonso C Silva

❮ Previous
Next ❯

Citations

Sep 14, 2017·Journal of Basic and Clinical Physiology and Pharmacology·Sepideh Saffarpour, Farinaz Nasirinezhad
Jul 14, 2021·Antioxidants & Redox Signaling·Christophe Glorieux, Pedro Buc Calderon
Jan 21, 2017·Analytical Chemistry·Tongfang XiaoLanqun Mao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.