PMID: 2116321Jul 16, 1990Paper

Coupling of early response gene expression to distinct regulatory pathways during alpha-interferon and phorbol ester-induced plasmacytoid differentiation of B chronic lymphocytic leukaemia cells

FEBS Letters
J J Murphy, J D Norton

Abstract

Phorbol esters (phorbol 12-myristate 13-acetate; PMA) and alpha-interferon (alpha-IFN) act through divergent signal transduction pathways to induce B chronic lymphocytic leukaemia cells (B-CLL) to undergo plasmacytoid differentiation in vitro. By using a panel of PMA-inducible early response gene probes we show that these two different effectors are coupled to second messenger pathways that do not converge on a common gene regulatory programme in differentiation of B-CLL cells. Moreover, using the calcium ionophore, A23187, four distinct regulatory classes of early response gene could be defined implying that multiple regulatory pathways may mediate the process of terminal differentiation in B lymphocytes.

References

Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C YanI Tamm
May 1, 1985·The Journal of Experimental Medicine·O LantzJ C Brouet

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Citations

May 10, 2003·Blood Cells, Molecules & Diseases·George B SegelNancy Wang

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