Coupling of methyl ketones and primary or secondary amines leading to α-ketoamides

The Journal of Organic Chemistry
Wei WeiXiaobing Wan

Abstract

A metal-free oxidative coupling of methyl ketones and primary or secondary amines to α-ketoamides has been developed. Four intermediates, α-iodoketone, α-aminoketone, iminium intermediate, and α-hydroxy amine have been identified through a series of control experiments. The atom-economic methodology can be scaled-up, tolerates a variety of functional groups, and is operationally simple.

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Citations

Feb 18, 2016·Chemical Reviews·Carmela De RisiVinicio Zanirato
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