Coupling the Circadian Clock to Homeostasis: The Role of Period in Timing Physiology

Endocrine Reviews
Pureum KimOliver Rawashdeh

Abstract

A plethora of physiological processes show stable and synchronized daily oscillations that are either driven or modulated by biological clocks. A circadian pacemaker located in the suprachiasmatic nucleus of the ventral hypothalamus coordinates 24-hour oscillations of central and peripheral physiology with the environment. The circadian clockwork involved in driving rhythmic physiology is composed of various clock genes that are interlocked via a complex feedback loop to generate precise yet plastic oscillations of ∼24 hours. This review focuses on the specific role of the core clockwork gene Period1 and its paralogs on intra-oscillator and extra-oscillator functions, including, but not limited to, hippocampus-dependent processes, cardiovascular function, appetite control, as well as glucose and lipid homeostasis. Alterations in Period gene function have been implicated in a wide range of physical and mental disorders. At the same time, a variety of conditions including metabolic disorders also impact clock gene expression, resulting in circadian disruptions, which in turn often exacerbates the disease state.

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Citations

Jun 9, 2020·PLoS Computational Biology·Hanxin ZhangAndrey Rzhetsky
May 12, 2020·Endocrine Reviews·Yong Hoon Kim, Mitchell A Lazar
Mar 12, 2020·Current Pharmaceutical Design·Mariano Ruiz-Gayo, Nuria D Olmo
Jul 29, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Yotam KolbenYaron Ilan
Mar 16, 2019·Frontiers in Endocrinology·Sonia Morales-SantanaMaría Morell
Jan 23, 2020·The European Journal of Neuroscience·Frank RavenRobbert Havekes
Apr 4, 2021·Biology·Juan Alfonso RedondoBenjamin Beck
Jul 3, 2021·Diagnostics·Bala S C KoritalaDavid F Smith
Jul 7, 2021·The FEBS Journal·Sarah Koop, Henrik Oster
Aug 14, 2021·Health Psychology Review·Allison C VerondaLeah A Irish
Sep 7, 2021·Physiological Reviews·Alan G WattsWolfgang Langhans
Oct 14, 2021·Molecular Biology Reports·Huihui JiangChengming Sun

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